Lawley, P. D. (1966) Mechanism of action of alkylating agents: comparison with other cytotoxic, mutagenic and carcinogenic agents. Molekulare Biologie des malignen Wachstums. Springer, Berlin-Heidelberg-New York, pp. 126-141Lawley, P. D. : Mechanism of action of alkylating agents: comparison ...
The reactivity of b... Franck Charmantray, Alain Duflos, Jean Lhomme and Martine Demeunynck - 《Journal of the Chemical Society Perkin Transactions》 被引量: 41发表: 2001年 Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole. Misonidazole (...
What is the mechanism of action of antimetabolites? Antimetabolites interfere withDNA and RNA synthesis by acting as false metabolites, which are incorporated into the DNA strand or block essential enzymes, so that DNA synthesis is prevented. Most agents are cell cycle phase specific for S phase....
Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature 1965;206:480-3.Lawley PD, Brookes P. Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature 1965;206:480-483....
Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder can...
The alkylating agents io... RF Luduena,MC Roach - 《Biochemistry》 被引量: 87发表: 1981年 Methods and compositions for treating cancer Pharmaceutical compositions and kits useful for the treatment of cancer include certain alkyl esters of cystine and certain alkyl-substituted cystamine derived ...
Export Citation for this Article Get Citation Alerts Request PermissionsAbstract References Cited By Get PDF (610K) Keywords: Neoplasma experimental; alkylating agent; antimetabolite; DNA; RNA; mutagens; nitrosocarbamate; mouse; rat; dog Abstract: LS 1727, a nitrosocarbamate of 19-nortestosterone, ...
Mechanism of action Lurbinectedin is a DNA alkylating agent.7 It covalently binds to guanine residues in the DNA minor groove, forming adducts that bend the DNA helix towards the major groove. This process triggers a cascade of events that affect the activity of transcription factors and impai...
Mechanism of action Glutathione (GSH) participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It also plays a role in the hepatic biotransformation and detoxification process; it acts as a hydrophilic molecule that is added to other lipophilic toxins or wastes ...