RemyelinationapoE isoformsBackground:Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellular debris upon myelin damage or ...
To directly test whether theAPOEgenotype contributes to LD accumulation in microglia,APOE4/4and isogenicAPOE3/3iPS cells16were differentiated into microglia (iMG) as previously described17,18,19(Fig.3aand Extended Data Fig.5a). Live cell microscopy of iMG with a fluorescent dye for neutral lipid...