f). To further investigate the effects of GNE-317 we performed RNA-seq ofAPOE4/4iMGs treated with fAβ in the presence or absence of the drug. GNE-317 reduced the expression of genes involved in lipid synthesis and reduced the genes indicative ...
com 【 Abstract】 The apolipoprotein E ( ApoE) is involved in cholesterol and lipid metabolism in the brain, transporting cholesterol to neurons and removing lipid debris to facilitate myelin repair. ApoE4, one of three subtypes of ApoE, is the most important genetic risk factor for sporadic ...
com 【 Abstract】 The apolipoprotein E ( ApoE) is involved in cholesterol and lipid metabolism in the brain, transporting cholesterol to neurons and removing lipid debris to facilitate myelin repair. ApoE4, one of three subtypes of ApoE, is the most important genetic risk factor for sporadic ...
After incubation, we depleted myelin debris by 30% isotonic Percoll (P1644; Sigma-Aldrich) gradient centrifugation and obtained mononuclear cell suspensions in DMEM/F12 medium with ice-cold 10% heat-inactivated fetal bovine serum. We prepared unstained controls from mixtures of different sample cell ...
The role of apoE derived from specific cell types such as astrocytes or microglia on tau pathology, neuroinflammation, and neurodegeneration is not understood but could differ in function. In a recent study, we found that astrocyte-derived apoE particles are significantly larger and thus contain ...
TRPV1 agonist capsaicin reduces MHC II-dependent antigen presentation and neuroinflammation of microglia in the context ofAPOE4-related tauopathy Extensive efforts have elucidated a crucial role of microglial immunoreactivity in drivingAPOE4-related tauopathy and neurodegeneration [2,3,4]. To test wheth...