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Overall, there is an urgent need to develop effective therapeutics to reverse or robustly attenuate pathological progression of AD and associated neurodegeneration. At the cellular level, AD is characterized by synaptic dysfunction and neurodegeneration, neuroinflammation, as well as vascular dysfunction [5...
White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs further ...
APOE binding to receptors either triggers the uptake of APOE or activates downstream singling cascades involving primarily mitogen-activated protein (MAP) kinases [15,16,17,61]. The APOE receptor-mediated ligand uptake represents the major mechanism of lipoprotein clearance in the periphery and lipid...
We provide a single-cell atlas describing the transcriptional effects of APOE4 on the aging human brain and establish a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease....
It is possible that our pattern is driven by similar factors, e.g., neuroinflammation. Indeed, the specificity of this pattern to the APOE4 genotype may be due to the role of APOE in blood-brain-barrier maintenance, vascular health, as well as inflammation regulation64. In line with our ...
USA). Tissue sections were manually scored for αSyn pathology on a scale of 0 (no pathology) to 3 (highest pathology) by three independent raters using the Allen Brain Atlas to define regions (Allen Reference Atlas—Mouse Brain [brain atlas]. Available from atlas.brain-map.org) [1,8,19...
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(e.g., amyloid and neuroinflammation-mediated) effects, as noted above. While the current study did not assess the impact of APOE2 allelic dose on ORs for these primary tauopathies, it found no association between APOE2 allele dose and ORs for four other disease (CAA, DLB, VBI, and HS)...