Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity doi:10.1002/cbdv.202400244Chemistry & BiodiversityTeng, XifengShi, HuiwenCao, LiudanPeng, XingHe, LinGu, Qiong
et al. Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma. Oncogene 42, 1209–1223 (2023). https://doi.org/10.1038/s41388-023-02636-3 Download citation Received27 October 2022 Revised12 February 2023 Accepted14...
“U” in T-SOD is a SOD activity unit, which is the amount of SOD per mg of protein when the SOD inhibition rate reaches 50% in 1 mL of reaction solution, and the “mmol/g prot” in T-AOC indicates that when a sample at a certain concentration has the same inhibition rate as ...
Gigantol, a naturally occurring dibenzyl compound derived from various orchid species within the Dendrobium genus, exhibits notable pharmacological activity. We found that gigantol has significant anti-lung cancer properties, both in vitro and in vivo, which it exerts through the induction of ferroptosis...
In addition, as a mechanism underlying the activation of Nrf2, Keap1 is accepted to be the main governor of Nrf2 activity. In a state of low oxidative stress, the cysteine residues on Keap1 are oxidized, leading to the release of Nrf2 from the Keap1/Nrf2 complex and...
The activity, spirit, and diet of the mice in each of the aforementioned mouse models were tracked daily before and after the experiment. Every four days, vernier calipers were used to measure the tumor’s long diameter (mm) and short diameter (mm). The tumor volume (V) of the mice ...
Interestingly, cholesterol promotes the progression of CD8+T cells towards ferroptosis via fatty acid uptake via CD36, and the use of ferroptosis inducers may inhibit their activity as well [25]. Therefore, the relationship between ferroptosis and immunotherapy does not necessarily exhibit a positive ...
Moreover, Pizotifen malate (PZM), a FDA-approved medication, bound to the Neh1 domain of NRF2 and prevented NRF2 protein binding to the ARE motif of target genes, suppressing transcription activity of NRF2. PZM treatment suppressed tumor development in ESCC PDX model by inducing ferroptosis via...
Significantly, we discovered that ZIO-101 and kinase inhibitors (Dasatinib/Dactolisib) could synergistically kill leukemia cells, with a combination index of <1.0 under all the tested drug concentrations. Our findings regarding the ferroptosis-mediated antileukemia activity of ZIO-101, based on the ...
As a result, we demonstrated the enhanced anti-cancer activity between these two botanical extracts in terms of their ability to inhibit cancer cell growth, suppress colony formation and induce apoptosis. Furthermore, we validated these findings in subcutaneous xenograft model and in patient derived ...