Results: We found that the ferroptosis inhibitor can modulate inflammatory response in MCAO mice, characterizing that the level of M2 microglia-related cytokines was increased. We then confirmed that different subtypes of microglia exhibit distinct sensitivities to I/R-induced ferroptosis. Adipose-derived...
(C) The proteins participated in “DNA replication”, “cell cycle”, “cell cycle G1-S phase transition” and “cyclin dependent protein serine threonine kinase regulator activity”, anti-ferroptosis markers as well as Wnt/β-catenin and Hippo signaling pathways were analyzed using western ...
In this study, by , and assessments, our results revealed that SCD1 exhibited the ability to promote tumor growth, migration and anti-ferroptosis of gastric cancer. The underlying mechanism might involve the alteration of cancer stemness and modulation of cell cycle-related proteins. Moreover, ...
Carboxymethyl cellulose/quaternized chitosan hydrogel loaded with polydopamine nanoparticles promotes spinal cord injury recovery by anti-ferroptosis and M1/M2 polarization modulation 羧甲基纤维素/季铵化壳聚糖水凝胶负载聚多巴胺纳米粒通过抗铁下垂和M1/M2极化调节促进脊髓损伤恢复...
caused by combined treatment with IFNγ and PUFAs (namely increased AA-PL synthesis and weakened ferroptosis defense) induce potent ferroptosis in tumor cells. Consequently, PUFA treatment enhances anti-tumor immunity and its combination with immune checkpoint blockade therapies (such as PD-1/PD-L1 ...
3. Antitumour treatment drugs and ferroptosis 3.1. Multikinase Inhibitors 3.1.1. Sorafenib Sorafenib, a multikinase inhibitor, has been approved by the US Food and Drug Administration (FDA) as a first-line treatment for unresectable hepatocellular carcinoma (HCC) [37], [38], [39]. This drug ...
antioxidants Article Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells Xican Li 1,2,*,† , Jingyuan Zeng 1,†, Yangping Liu 3, Minshi Liang 1,2, Qianru Liu 1,2, Zhen...
Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization 来自 EBSCO 喜欢 0 阅读量: 93 作者:M Chen,J Li,G Shu,L Shen,E Qiao,N Zhang,S Fang,X Chen,Z Zhao,J Tu 摘要: Transcatheter arterial chemoembolization (TACE) is one of the ...
et al. Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS. Cell Mol Biol Lett 28, 36 (2023). https://doi.org/10.1186/s11658-023-00449-6 Download citation Received20 ...
Targeted therapy attempts are needed to enhance esophageal squamous cell carcinoma (ESCC) patients’ overall survival and satisfaction of life. Nuclear factor erythroid 2-related factor 2 (NRF2), as a high-confidence cancer driver gene, controls the anti