Selenium plays an essential role in reducing lipid peroxidation generated during ferroptosis through its incorporation into the catalytic site of glutathione peroxidase 4. Here, we compared the anti-ferroptotic activity of several organic and inorganic selenium compounds: methylselenocysteine, selenocystine, ...
Within this context, our findings posit silibinin as a potential therapeutic candidate possessing antiferroptotic properties in SCI model. Therapeutic agents capable of effectively and safely mitigating ferroptotic cell death hold the potential to be critical points of future clinical investiga...
In conclusion, in the present work we have demonstrated that in subjects with severe HF with reduced ejection fraction, treatment with SGLT-2i is associated with reduced inflammation and pro-inflammatory immune cell infiltration and an anti-inflammatory and anti-ferroptotic shift in the lipid spectr...
preliminarily investigated the anti-ferroptosis effect of indigo in inflammatory bowel disease. Here, we further discuss and evaluate the role of indigo based on the results.Shaopeng,SunMolecular Profiling Research Center for Drug Discovery (Molprof) National Institute of AdvancedBin,Lv...
Focused on temporal aspects of cytotoxicity/protection, we investigated the effects of classic (Fer-1) and novel [2,6-di- tert -butyl-4-(2-thienylthio)phenol ( C1 ) and 2,6-di- tert -butyl-4-(2-thienylselano)phenol ( C2 )] anti-ferroptotic agents against RSL3-, BSO- or ...
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effectsMetforminVascular calcificationFerroptosisPeriostinp53Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting from iron-dependent excessive lipid peroxidation. Elevated plasma levels ...
In vitro and in vivo studies showed the anti-ferroptotic and anti-inflammatory effects of FPAaF micelles. Moreover, significant improvements in neural and motor recovery were achieved upon the release of Fer-1 and aFGF in the acidic SCI microenvironment, which resulted in anti-ferroptotic and ...
Whether inside the "producer" IDO1 + cell or the "receiver" cell, KYN is converted into downstream metabolites, suppressing ferroptosis by ROS scavenging and activating an NRF2-dependent, AHR-independent cell-protective pathway, including SLC7A11, propagating anti-ferroptotic signaling. IDO1, ...
Curcumin exerts anti-inflammatory, antioxidant and anti-ferroptotic effects through the Nrf2/HO-1 pathway to protect cardiomyocytes against sepsisdoi:10.22514/sv.2024.057Cardiomyocytes; Curcumin; Sepsis; Nrf2/HO-1; Ferroptosis; Oxidative stress; Inflammation...
Importantly, the anti-oxytotic/ferroptotic character of the quinone compounds relied on their capacity to target and directly prevent lipid peroxidation in a manner that required the reducing activity of cellular redox enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and ferroptosis ...