MetforminVascular calcificationFerroptosisPeriostinp53Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids are tightly associated with cardiometabolic risk factors in patients with ...
The analysis combined complex metabolomics and gene expression analysis, along with immunohistochemistry and flow cytometry, to identify possible cardioprotective factors and pathways associated with SGLT-2i treatment. Methods Study subjects This was a cross-sectional clinical trial, performed in subjects ...
At first, Cell viability was measured using Cell Counting Kit 8 (CCK-8) and Cell-Light 5-ethynyl-2-deoxyuridine (EdU) staining, and inflammatory factors tumor necrosis factor-伪 (TNF-伪), interleukin 6 (IL-6), interleukin 1尾 (IL-1尾), oxygen species (ROS), malondialdehyde (MDA), ...