preliminarily investigated the anti-ferroptosis effect of indigo in inflammatory bowel disease. Here, we further discuss and evaluate the role of indigo based on the results.Shaopeng,SunMolecular Profiling Research Center for Drug Discovery (Molprof) National Institute of AdvancedBin,Lv...
However, as the effect of SGLT-2i on HF improvement was present across a wide range of glomerular filtration rates and also in subjects with substantial renal impairment, glycosuric action does not seem to be the only responsible factor [13]. In fact, a number of other contributing ...
Interestingly, overexpression of p53 attenuates the inhibitory effect of POSTN on SLC7A11 expression, accompanied by increased Gpx4 expression. Furthermore, p53 knockdown suppresses Met-mediated anti-ferroptosis effects in PA-treated VSMCs, which may be related to the downregulation of SLC7A11 ...
Cardiomyocytes; Curcumin; Sepsis; Nrf2/HO-1; Ferroptosis; Oxidative stress; InflammationThis study explores the therapeutic effect of curcumin on H9c2 rat cardiac myoblasts in vitro sepsis model and its potential mechanisms. At first, Cell viability was measured using Cell Counting Kit ...
The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomideferroptosisglioblastomaTRIM7doi:10.1002/cai2.77Luyao WangRongyang XuChengying HuangS. QuCancer Innovation
We show that this effect requires KYN export from IDO1-expressing cells, which is then available for non-IDO1-expressing cells via SLC7A11, the central transporter involved in ferroptosis suppression. Whether inside the "producer" IDO1 + cell or the "receiver" cell, KYN is converted into ...
Because some of the compounds increased the production of total reactive oxygen species while decreasing lipid peroxidation, it appears that the pro-oxidant character of a compound can coexist with an inhibitory effect on lipid peroxidation and, consequently, still prevent oxytosis/ferroptosis. These ...