Compounds 1 and 12 exhibited significant inhibitory effects against HT-22 cells ferroptosis induced by RSL3, with EC 50 values of 11.8 ± 1.0 μM, and 4.52 ± 1.24 μM, respectively. Moreover, ROS accumulation in HT22 cells treated with compound 1 was also observed. Graphical Abstract...
Curcumin and Andrographis Exhibit Anti-Tumor Effects in Colorectal Cancer via Activation of Ferroptosis and Dual Suppression of Glutathione Peroxidase-4 an... Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The limitations of current chemotherapeutic drugs in CRC include...
S3A,B). To investigate the antitumor effects of 5-FU plus Corilagin, SW480 cells were incubated with a fixed ratio concentration (1:3) of Corilagin and 5-FU in combination for 48h and cell survival was assayed. The results showed that the combination of 5-FU and Corilagin significantly ...
(2022) Transcriptomic Analysis Uncovers Immunogenic Characteristics of Ferroptosis for Myocardial Infarction and Potential Therapeutic Prediction of Chinese Herbs. Evid Based Complement Alternat Med 2022: 4918343. Juan YH, et al. Alpha-mangostin alleviate renal interstitial fibrosis via suppression of TGF-...
Canagliflozin improves fatty acid oxidation and ferroptosis of renal tubular epithelial cells via FOXA1-CPT1A axis in diabetic kidney disease. Mol Cell Endocrinol. 2024;582: 112139. Article CAS PubMed Google Scholar Westbrook R, et al. Alterations in oxygen consumption, respiratory quotient, and ...
Baicalein could directly bind to JAK2 protein and inhibit JAK kinase activity to downregulate the JAK2/STAT3/GPX4 axis,increasing the accumulation of lipid peroxides and trigger ferroptosis in colorectal cancer cells[98]. The clinical application of baicalein in the treatment of colorectal cancer can ...
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aspect, in particular how dietary chili peppers and capsaicin consumption reduce body weight and its potential mechanisms of its anti-obesity effects. With... Z Jia,Z Sheng,Q Feng,... - 《Bioscience Reports》 被引量: 2发表: 2017年 Arvanil induces ferroptosis of hepatocellular carcinoma by bin...
ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Signal Transduct Target Ther. 2022;7(1):288. Published 2022 Aug 15. https://doi.org/10.1038/s41392-022-01090-z Chazelas P, Steichen C, Favreau F, et al. Oxidative...
CD8(+) T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell 40, 365–378 e366 (2022). Article CAS PubMed PubMed Central Google Scholar Baumgartner, C. K. et al. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature ...