Fatty acid synthase: a novel target for antiglioma therapy. High levels of fatty acid synthase (FAS) expression have been observed in several cancers, including breast, prostate, colon and lung carcinoma, compared w... - 《British Journal of Cancer》 被引量: 73发表: 2006年 Glioma-associated...
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
If and when such studies in humans become feasible, correlation with FASN protein expression in tumors will need to be closely examined, and may have some significance to therapy response. Although the data we have demonstrated on fatty acid synthase is intriguing and raises the possibility that ...
Fatty Acid Synthesis and Prostate Cancer: Hormonal Regulation and Anti- Metabolite Targeting of an Acquired Function in NeoplasiaSynthesisClinical medicineGrowth(Physiology)Prostate glandFatty acidsAntimetabolitesProstate cancerActivationHormonesTissues(Biology)...
However, the functional properties of Satureja fatty acid have not been explored. This study examined the fatty acid profile, lipid nutritional quality, antioxidant, anti-amylase, and anti-lipase capacities of Satureja. The efficiency of Satureja fatty acid on the anti-oxidative and anti-inflammatory...
To investigate the mechanism by which TH produces a fatty liver, we performed the following studies in regard to the fatty acid synthesis in rat liver. Male Donryu rats weighing 100 to 150g were used. They were sacrificed at a fixed time after the administration of TH (60 to 200mg/kg ...
As recent studies have confirmed that chronic low- grade inflammation is closely associated with metabolic syn- dromes[3, 4], anti-inflammatory therapy is a potential approach for treating cardiovascular disease and type 2 diabetes. GPR120, an ω-3 fatty acid receptor, is abundantly expressed in...
The intrahepatic regulation of free fatty acid uptake, synthesis, degradation, and secretion is altered, which leads to accumulation of triglycerides in the hepatocytes. These changes in morphology cause the liver to be susceptible to injury from inflammatory responses which aid in the progression of ...
block copolymers, ADC/ProTAC linkers, biodegradable polymers, exosomes, viral-like particles, as well as providing CDMO and solution services. These products are widely used in long-acting protein/peptide drugs, COVID-19 mRNA vaccines, small nucleic acid drugs, blood sugar control drugs, macromolec...
(PLP), will require for its therapy a peptide of MBP, MOG or PLP or an analogue thereof; myasthenia gravis can be treated with a peptide from the acetylcholine receptor; thyroiditis with a peptide from thyroglobulin; diabetes type 1 with a peptide of glutamic acid decarboxylase (GAD) or a ...