Design and Synthesis of Fatty Acid Synthase Inhibitors with Anti-Mycobacterial PropertiesMinerva A. Hughes
In cakes, as well as seeds, the concentration of linoleic acid (omega-6) was larger in , while linolenic acid (omega-3) was found in greater ... C Ruiz,C Díaz,J Anaya,... - 《Revista De La Sociedad Química Del Perú》 被引量: 0发表: 0年 ...
Eventually, the structure of 1 was unequivocally determined as (9Z,16R)-16-hydroxy- 9-octadecenoic acid. The structure of 1 was also confirmed by chemical synthesis.12 The 1H NMR spectra obtained from 2 are similar to those of 1. With molecular formula of C18H32O3, the structure of 2 ...
The pathogenesis of NAFLD is a multifactorial and complex process. The intrahepatic regulation of free fatty acid uptake, synthesis, degradation, and secretion is altered, which leads to accumulation of triglycerides in the hepatocytes. These changes in morphology cause the liver to be susceptible to ...
The inflammatory processes are known to be triggered by increased metabolic activity of arachidonic acid. Arachidonic acid diverges down into two main pathways during this process, the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. The COX pathways lead to prostaglandins and thromboxane production...
For the first time, we demonstrated that Rb2 could enhance the inhibitory effect of ω-3 fatty acid on the LPS-induced inflammatory process in RAW264.7 macrophages by increas- ing GPR120 expression. Furthermore, we proved that this enhancing effect of Rb2 was strictly dependent on GPR120 ...
Using the 3 T3-L1 preadipocyte cell line, we determined that α-ESA was far less potent than its non-conjugated counterpart, α-linolenic acid, or other common unsaturated C18 fatty acids in stimulating adipocyte differentiation [3]. This effect was partly ascribed to the apoptotic effect of α...
To clarify whether resistin implicates hepatic glucose production and hepatic fatty acid synthesis, the gene expressions involved in hepatic gluconeogenesis and lipogenesis pathways were detected. mRNA expression of PEPCK and SREBP-1c was significantly increased in HFD control group as compared with chow ...
Paraffin sections (3 μm thick) of the fixed and processed kidneys were stained with periodic acid/Schiff (PAS) reagent or Masson-Trichrome. To assess the mesangial expansion, 20 glomeruli, that were randomly selected from each rat were cut at the vascular pole, and the periodic acid/Schiff...
A. Synthesis and anti-tumor activity of a novel inhibitor of fatty acid synthase. Proc. Natl. Acad. Sci. USA, 97: 3450 - 3454, 2000.Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA: Synthesis and anti-tumor activity of a novel inhibitor of fatty acid synthase. ...