Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
摘要: Antimicrobial agent particularly effective as an antiviral agent but also exhibiting antifungal and antibacterial activity characterized as a triad containing peptide, fatty acid and carbohydrate moieties.收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 Anti-viral substance containing peptide,...
Consequently, the goal of this work is to find out the potential regulatory mechanisms of HPSIDF on hepatic fatty acid oxidation by determining changes in fatty acid oxidation-related enzymes in mitochondria and peroxisomes, the production of oxidation intermediates and final products, the ...
Keywords: ginsenoside Rb2; LPS; α-linolenic acid; RAW264.7 cells; GPR120; inflammatory cytokines; iNOS; COX-2; IKK/NF-κB; MAPK pathway; diabetes; chronic inflammation Acta Pharmacologica Sinica (2017) 38: 192–200; doi: 10.1038/aps.2016.135; published online 26 Dec 2016 Introduction ...
[1,2]. One of the important metabolites that is produced by gut microbiota is short chain fatty acid (SCFA). The major SCFA are acetic, butyric and propionic (≥ 95%) acids, whereas formic, valeric, caproic acids, etc., make up the remaining SCFA [3], whereby they reduce the ...
acid (HETEs). These classes of inflammatory molecules exert profound biological effects, which enhance the development and progression of human cancers. Inhibition of 5-lipoxygenase indirectly reduces the expression of TNF-α. Both 5-Lipoxygenase and TNF-α therefore, are the target enzymes useful ...
in 1950 [24], which are superfamily enzymes that catalyze the hydrolysis of fatty acid acyl coenzyme a to form free fatty acids (FFA) and coenzyme a (CoA) [25]. Moreover, the family of ACOTs contributes to tumor development, like ACOT4 binds to B7 homolog 4 (B7H4) in tumor-...
In studies of fish oil supplements, absorption rate of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) was usually greatest for the FFA form relative to the triglyceride form, and lowest for the EE form. This was attributed to esterified forms requiring hydrolysis by pancreatic enzymes (...
A major interest has been the search for selective inhibitors of the various enzymes in the arachidoric acid cascade. This is critical for the development of compounds with therapeutic potential for control of the pathological processes mediated by arachidonic acid metabolites, and is also important ...
The intrahepatic regulation of free fatty acid uptake, synthesis, degradation, and secretion is altered, which leads to accumulation of triglycerides in the hepatocytes. These changes in morphology cause the liver to be susceptible to injury from inflammatory responses which aid in the progression of ...