Incubating glioma cells with the FAS inhibitor cerulenin decreased endogenous fatty acid synthesis by approximately 50%. Cell cycle analysis demonstrated a time- and dose-dependent increase in S-phase cell arrest following cerulenin treatment for 24h. Further, treatment with cerulenin resulted in time...
This project seeks to characterize androgen mediated and androgen independent mechanisms for fatty acid synthesis pathway activation during prostate cancer progression, using cell culture and animal models of prostate cancer, and analyzing human tumor tissue in parallel. It further seeks to evaluate the ...
Fatty acid synthase and cancer: new application of an old pathway. Cancer Res. 2006;66(12):5977–80. Article CAS PubMed Google Scholar Huang C, Ou R, Chen X, et al. Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating...
Nur77Anti-inflammatory activityω-3 polyunsaturated fatty acidMolecular dockingAcute lung injuryIn this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was evaluated. Compounds 4a, 4f, ...
There are two pathways for arachidonic acid metabolism (1) the cycloxygenase pathway which leads to the formation of prostaglandins and thromboxanes, and (2) the lipoxygenase pathway which is responsible for the generation of leukotrienes and lipoxins. These metabolites, collectively called eicosanoids,...
To investigate the mechanism by which TH produces a fatty liver, we performed the following studies in regard to the fatty acid synthesis in rat liver. Male Donryu rats weighing 100 to 150g were used. They were sacrificed at a fixed time after the administration of TH (60 to 200mg/kg ...
well defined, prior studies have suggested that epa-induced downregulation of proinflammatory mediators occurs by displacing arachidonic acid in mø membrane, thereby inhibiting the cyclooxygenase 2 pathway and decreasing production of angiogenic growth factors, including vascular endothelial growth factor α...
Pulp Phenolics Activate the Short-Chain Fatty Acid-Free Fatty Acid Receptor Anti-inflammatory Pathway by Regulating Microbio... Lychee (Litchi chinensisSonn.) Pulp Phenolics Activate the Short-Chain Fatty Acid-Free Fatty Acid Receptor Anti-inflammatory Pathway by Regulating Microbiota ... G Huang,Z ...
[1,2]. One of the important metabolites that is produced by gut microbiota is short chain fatty acid (SCFA). The major SCFA are acetic, butyric and propionic (≥ 95%) acids, whereas formic, valeric, caproic acids, etc., make up the remaining SCFA [3], whereby they reduce the ...
a multi-omics database, TNBC were classified into three subtypes based on different metabolic profiles, metabolic-pathway-based subtype 1 (MPS1),MPS2,MPS3, of which MPS1 is associated with lipid metabolism and is more sensitive to inhibitors targeting the synthesis of fatty acid metabolism [8]...