In this review, we will highlight our recent progress in understanding the mechanism of FASN-induced resistance.XiWuLiQinValerieFakoJian-TingZhangSDOSAdvances in Biological RegulationWu X, Qin L, FakoV, elal. Molecular mechanisms offatty acid synthase ( FASN ) -mediated resistance Io anti-...
To investigate the mechanism by which TH produces a fatty liver, we performed the following studies in regard to the fatty acid synthesis in rat liver. Male Donryu rats weighing 100 to 150g were used. They were sacrificed at a fixed time after the administration of TH (60 to 200mg/kg ...
Fatty Acid Synthesis and Prostate Cancer: Hormonal Regulation and Anti- Metabolite Targeting of an Acquired Function in NeoplasiaFatty Acid Synthesis and Prostate Cancer: Hormonal Regulation and Anti- Metabolite Targeting of an Acquired Function in NeoplasiaSynthesisClinical...
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
-linolenic acid, a precursor of ω-3 fas, is metabolized in the liver to longer-chain fas called eicosapentaenoic acid (epa) and docosahexaenoic acid (dha). eicosapentaenoic acid and dha are considered the most biologically active forms of ω-3 fas. consumption of epa has been associated with...
In addition, experi- ments were designed to identify the novel anti-inflammatory mechanism of Rb2, which involves improving the efficacy of ω-3 fatty acid-induced GPR120 activation in LPS-stimulated RAW264.7 cells. Methods and materials Reagents Ginsenoside Rb2 (purity >98.0%) was purchased ...
Bindarit [2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid] is a synthetic indazolic derivative with prominent anti-inflammatory activity, that has been shown to be safe and particularly effective in the treatment of several experimental inflammatory and autoimmune disorders, from viral and...
These results indicated that ICIs could affect the expression of fatty acid metabolism relevant gene, and the state of the immune microenvironment were related to the expression of fatty acid metabolism relevant gene, which suggested immunomodulatory effects might regulate the mechanism of fatty acid ...
acid (EPA) and docosahexaenoic acid (DHA) have a beneficial effect on CVD through reprogramming of TRL metabolism, reducing inflammatory mediators (cytokines and leukotrienes), and modulation of cell adhesion molecules. Therefore, the purpose of this review is to provide the molecular mechanism ...
(HSL) and fatty acid re-esterification (DGAT2) and measured upregulation of GYK expression [52] upon HF/n-3. Furthermore, our expression data are consistent with an increase in fatty acid uptake (LPL and CD36) and storage (GYK and LDHB), TAG synthesis (DGAT1, DGAT2, AGPAT9), as ...