In vitrostudies showed that 1-acetoxypinoresinol completely reduced the fatty acid synthase (FASN) levels in HER2 gene-amplified SKBR3 breast cancer cells, which naturally overexpress this protein, and in MCF7 breast cancer cells engineered to overexpress the HER2 tyrosine kinase receptor (Menendez ...
Herein, we reviewed the molecular pharmacology of inflammation, chemical components and biological activities of few medicinal plants as well as their mechanism of action during inflammation at the molecular levels. As a fundamental biological process which was regarded as the most frequent sign of dise...
29.A method of inhibiting adipocyte fatty acid-binding protein expression, comprising:administering a composition according to claim 1 to a mammal exhibiting allergic airway inflammation. 30.The method of claim 29, wherein said second extract component consists of an extract ofAegle marmelos. ...
H. et al., Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor, Molecular Pharmacology, 2012, p. 843-859, vol. 82, No. 5. Lin, D. D. H. et al., AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin ...
In Chinese medicine, ginseng (Panax ginseng C.A. Meyer) has long been used as a general tonic or an adaptogen to promote longevity and enhance bodily functions. It has also been claimed to be effective in combating stress, fatigue, oxidants, cancer and d
endothelial nitric oxide synthase FFA: free fatty acid TG: triglycerides GPx: glutathione peroxidase GR: glutathione reductase GST: glutathione S-transferase HB: hemoglobin HbA1c: glycated hemoglobin HDL: high density lipoprotein HFD: high-fat diet HG: high glucose HMG-CoA: 3-hydrox...
5-Benzylidenerhodanine-3-acetic acid derivatives 18 (Scheme 5) were reported to possess inhibitory activity against T. brucei dolicholphosphate mannose synthase and glycosylphosphatidylinositol anchor synthesis, as well as in vitro trypanocidal activity against the bloodstream form and were non-cytotoxi...
Chemistry Pharmacology, Toxicology and Pharmaceutical ScienceDiscover other topics On this page Chapters and Articles Related Terms Recommended Publications Featured Authors Chapters and Articles You might find these chapters and articles relevant to this topic. Allergic disorders Kamyar M. Hedayat, Jean-Cl...
FASNFatty acid synthase2.16 HADHBTrifunctional enzyme subunit beta, mitochondrial2.13 CLUHClustered mitochondria protein homolog/KIAA06642.12 ATP5IATP synthase subunit e, mitochondrial1.98 ABAT4-aminobutyrate aminotransferase, mitochondrial1.97 CLPXATP-dependent Clp protease ATP-binding subunit clpX-like,1.94 ...
Further supporting the notion, MafB could similarly activate the promoter of human fatty acid synthase (FASN) (0.82k upstream of TSS) (Fig. 3g and Supplementary Fig. S3), which also contains an established LXR binding motif (TGACCGgcagTAACCC). However, MafB failed to activate a shorter FASN...