A novel inhibitor of fatty acid synthase shows activity against HER2þ breast cancer xenografts and is active in anti-HER2 drug- resistant cell lines. Breast Cancer Res 2011;13:R131.Puig T,Aguilar H,CufíS,et al.A novel inhibitor of fatty acid synthase shows activity against HER2+breast ...
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
bMCF7 breast cancer cell,cHT-29 colon cancer cell anddTHP-1 leukaemia cancer cell. The initial concentration of individual SCFA for cytotoxicity analyses was prepared according to the highest concentration of SCFA (Acetic acid = 23.89 mM; Butyric acid ...
The biosynthesis of prostaglandin E(2) (PGE(2)) from [1-(14)C]arachidonic acid has been demonstrated in homogenates and subcellular fractions of human epidermis. This biosynthetic capacity is localized in the microsomal fraction, indicating the presence of an active prostaglandin synthetase system as...
(LTS) and hydroxyl eicosatetraenoic acid (HETEs). These classes of inflammatory molecules exert profound biological effects, which enhance the development and progression of human cancers. Inhibition of 5-lipoxygenase indirectly reduces the expression of TNF-α. Both 5-Lipoxygenase and TNF-α therefore...
Met downregulated expression of enzymes of fatty acid de novo synthesis, such as ATP Citrate Lyase (ACLY), Fatty Acid Synthase (FAS), Fatty Acyl-CoA Elongase 6 (ELOVL6), and Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells. In conclusion, CA mediated reprogramming of glucose processing ...
FFA free fatty acid ADH alcohol dehydrogenase AMPK adenosine 5′-monophosphate-activated protein kinase SREBP-1c sterol regulatory element binding protein 1c PPAR peroxisome proliferation-activated receptor FAS fatty acid synthase ACOX1 acyl-coenzyme A oxidase 1 Ucp1 uncoupling protein 1 Adrb3 adrenorec...
In addition to the accumulation of arachidonic acid, COPD patients were found to accumulate pentadecanoic acid, docosatetraenoic acid, stearic acid, ecosanic acid, and decrease in linoleic acid, eicosapentaenoic acid, and docosapentaenoic acid. The detected imbalance corresponded to increased accumulation...
FAG composition was as follows: palmitic acid (10% by weight), oleic acid (10% by weight), stearic acid (10% by weight), linoleic acid (1% by weight), α-linolenic acid (1% by weight), γ-linolenic acid (0.5% by weight), eicosapentaenoic acid (3% by weight) and docosahexaenoic ...