Design and Synthesis of Fatty Acid Synthase Inhibitors with Anti-Mycobacterial PropertiesMinerva A. Hughes
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene 2005;24:39–46. 14 Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844–847. 15 Tavassoli FA,...
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003;63(21):7330–7. CAS PubMed Google Scholar Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA. ...
摘要: Antimicrobial agent particularly effective as an antiviral agent but also exhibiting antifungal and antibacterial activity characterized as a triad containing peptide, fatty acid and carbohydrate moieties.收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 Anti-viral substance containing peptide,...
The structure of 1 was also confirmed by chemical synthesis.12 The 1H NMR spectra obtained from 2 are similar to those of 1. With molecular formula of C18H32O3, the structure of 2 was predicted to be a C18 fatty acid with two olefinic double bonds and one hydroxyl group. In fact, the...
Fatty Acid Synthesis and Prostate Cancer: Hormonal Regulation and Anti- Metabolite Targeting of an Acquired Function in NeoplasiaSynthesisClinical medicineGrowth(Physiology)Prostate glandFatty acidsAntimetabolitesProstate cancerActivationHormonesTissues(Biology)...
a multi-omics database, TNBC were classified into three subtypes based on different metabolic profiles, metabolic-pathway-based subtype 1 (MPS1),MPS2,MPS3, of which MPS1 is associated with lipid metabolism and is more sensitive to inhibitors targeting the synthesis of fatty acid metabolism [8]...
The potential mechanisms of action of omega-3 acids in coronary heart disease risk reduction are based on their anti-arrhythmic, anticoagulant, anti-inflammatory, vascular endothelial function-improving, and hypotensive and triglyceride level-reducing properties. Docosahexaenoic acid, (DHA) originating from...
Herbal compositions having anti-adipocyte fatty acid-binding protein (aP2), anti-5-lipoxygenase-activating protein (FLAP) and anti-Cysteinyl Leukotriene (CysLT)-1 receptor expression activity contain an extract ofBoswellia serrata. More particularly, these herbal compositions comprise an effective amount...
A major interest has been the search for selective inhibitors of the various enzymes in the arachidoric acid cascade. This is critical for the development of compounds with therapeutic potential for control of the pathological processes mediated by arachidonic acid metabolites, and is also important ...