When the fatty acid and diltiazem were present simultaneously this ratio was decreased to 0·93, suggesting that, in spite of the inhibition of oxygen uptake, the respiratory chain was not rate limiting for the oxidation of the reducing equivalents coming from β-oxidation. In experiments with ...
Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer Cen Jiang, Youzhi Zhu, Huaying Chen, Junyu Lin, Ruiwang Xie, Weiwei Li, Jiajie Xue, Ling Chen, Xiangjin Chen & Sunwang Xu Cell Death & Disease volume 14,...
Am J Physiol Heart Circ Physiol 285: H1626-H1631, 2003; 10.1152/ajpheart.00332.2003.—This study tested the hypothesis that an acute infusion of β-hydroxybutyrate inhibits myocardial fatty acid uptake and oxidation in vivo. Anesthetized pigs were untreated (n = 6) or treated with an ...
The oxidation of NADPH was monitored via UV–Vis spectroscopy and the slope of the 340 nm absorbance was used for comparing relative activity between HMG-CoA containing samples and control samples. The addition of HMG-CoA led to a reduction in activity of FAS, with activity plateauing at ~...
Moreover, PA supplementation has been demonstrated to enhance fatty acid oxidation, oxygen consumption, and ATP production in white adipocytes. It also reduces hepatic steatosis and regulates both fatty acid oxidation and lipogenesis in the adipose tissue of obese mice [16,17,18,19,20]. Further,...
TSL-E significantly decreased lipid accumulation, stimulated free fatty acid (FFA) release, and up-regulated peroxisome proliferator-activated receptor-α (PPARα) and genes involved in peroxisomal (acyl-CoA oxidase) and mitochondrial (uncouple protein 3) fatty acid oxidation. TSL-E also up-...
Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in the accumulation of intracellular TG. We also determined the potential role of 5'-AMP-activated protein...
The identification of several proteins that have previously been documented to interact with viperin, such as Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha and Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta (fatty acid β-oxidation) (37), Cytosolic ...
Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid β-oxidation. Biol Trace Elem Res. 2012;150(1-3):360-70.Kim JE, Choi SI, Lee HR, Hwang IS, Lee YJ, et al. (2012) Selenium significantly inhibits adipocyte ...
and tiliroside, the principal constituent of its seeds, exhibit anti-obesity and anti-diabetic activities via enhancement of fatty acid oxidation in the liver and skeletal muscle. However, the effects of rosehip, the fruit of this plant, extract (RHE), or tiliroside on lipid accumulation in ...