1. 脂肪酸合成酶抑制剂 胰脂肪酶抑制剂,pancreatic... ... ) lipase inhibitor 脂肪酶抑制剂 )fatty acid synthase inhibitor脂肪酸合成酶抑制剂... www.dictall.com|基于3个网页 2. 脂肪酸合酶抑制子 ...率增加和脂肪贮存的再次积累,其存在机制可能相当于用脂肪酸合酶抑制子(fatty acid synthase inhibitor...
The present disclosure relates to a method for inhibiting Fatty Acid. Synthase (FASN) with, a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASNJesse KwiekTimothy HaysteadPhilip HughesYazan Alwarawrah...
Fatty acid synthase inhibitor Denifanstat, afatty acid synthase inhibitor, has decreased liver steatosis and inhibited inflammatory and fibrogenic pathways. The FASCINATE-1 (A Phase 2, Multi-Center, Single-Blind, Randomized, Placebo-Controlled Study of TVB 2640 in Subjects With Non-Alcoholic Steatohep...
公开/公告日期: 2001-03-01 申请(专利权)人: SMITHKLINE BEECHAM CORPORATION 发明人: Robert A. Daines,Siegfired B. Christensen IV,Jack D. Leber,Martha S. Head 被引量: 14 摘要: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.收藏...
Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FASN inhibitors (FASNis), which is a major roadblock to thei...
专利名称：FATTY ACID SYNTHASE, INHIBITORS AND MODIFICATIONS THEREOF AND ITS USE 发明人：CHARI, Ashwin,STARK, Holger,SINGH,Kashish,GRAF, Benjamin Moritz 申请号：EP19163958.2 申请日：20190320 公开号：EP3712263A1 公开日：20200923 专利内容由知识产权出版社提供 专利附图：摘要：In a first aspect, the ...
Fig. 1: Statins induce protein HMGylation on fatty acid synthase. Statins raise HMG-CoA levels in cells and mice resulting in HMGylated FAS. a Treating HepG2 cells for 24 h with simvastatin results in increased HMG-CoA levels with no change to other measured CoAs (p < 0.001, ...
FATTY ACID SYNTHASE INHIBITOR AND ITS USE 有效 基本信息 申请人信息 代理人信息 摘要 法律状态 权利要求 说明书 基本信息 申请号 WOCN06003402 申请日 2006-12-13 授权公告号 WO2008061399A1 授权公告日 - 优先权号 - 优先权日 - 分类号 A61P31/06; C07D207/50 申请人信息 申请(专利权)人 发明人...
Fatty Acid Synthase Fatty acid synthesis in animals is catalyzed by a single large (molecular weight, ∼5 × 105) multifunctional enzyme. All eight steps and thus all eight catalytic centers that carry out fatty acid synthesis occur with the intermediates tethered to the FAS. The intermediates ...
Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the de novo synthesis of long chain fatty acids. hFAS is highly expressed in a number of cancers, with low expression observed in most normal tissues. Although normal tissues tend to obtain fa...