Mouse models of Alzheimer's dementia: current concepts and new trends. Endocrinology. 2008;149:5952-5957.Torres-Aleman I. Mouse models of Alzheimer's dementia: current concepts and new trends. Endocri- nology. 2008; 149(12):5952-7. doi: 10.1210/en.2008-0905 PMID: 18818286...
Microglia limit the expansion of beta-amyloid plaques in a mouse model of Alzheimer’s disease. Mol. Neurodegener. 12, 47 (2017). PubMed PubMed Central Google Scholar Grathwohl, S. A. et al. Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of ...
L. et al. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol. Dis. 33, 213–220 (2009). Article CAS Google Scholar Sydow, A. et al. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice ...
The PS19 model is a traditional (non-controllable) transgenic line in which the human 4R tau with the P301S mutation is controlled by the mouse prion promoter, resulting in ~5-fold overexpression compared to the endogenous mouse tau [33]. The tau phenotype is considerably milder than that ...
Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer’s disease. J. Neurochem. 2005;94(6):1711–8. Article CAS PubMed Google Scholar Palop ML, Jorge J, Brian J, Lisa K, Chin Jeannie Y, Gui-Qiu RJ, Eliezer M. Neuronal depletion of calcium-dependent ...
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease Proc Natl Acad Sci USA, 99 (2002), pp. 10843-10848 View in ScopusGoogle Scholar Devilee et al., 2001 P. Devilee, A.M. Cleton-Jansen, C.J. Cornelisse Ever since Knud...
Intriguingly, a recent report generated chimeric models of human neurons transplanted into an AD mouse model to investigate the susceptibility of human cells to Aβ. The human neurons showed significant neurodegeneration, in contrast to mouse neurons, which were unaltered in number. Interestingly, the...
In contrast to these observations, hyperactivity (rather than inhibition) of calcineurin in reactive astrocytes has been shown to mediate the neuroprotective and nootropic effects of IGF-1 in an AD mouse model through interactions with PPARγ signaling pathways, though a more recent study found that...
Blocking adult neurogenesis in an AD mouse model exacerbated neuronal loss and cognitive impairment, while inducing neurogenesis together with brain-derived neurotrophic-factor-improved cognition [17]. Impaired neurogenesis in early-stage AD and MCI (mild cognitive impairment) patients raises the ...
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122, 1377 (2012). Article CAS PubMed PubMed Central Google Scholar Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D. & Winkler, E. A....