Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA Meichen Yu, Olaf Sporns & Andrew J. Saykin Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA Meichen Yu, Olaf Sporns & Andrew J....
The research team used a fluorescent compound called curcumin to label and detect retinal plaques. This is believed to be the first use of curcumin as an imaging agent to detect Alzheimer's disease-related plaques in the retinas of live animals. Curcumin, a natural component of the spice turme...
Non-human primate models for Parkinson's disease Section editors:Margreet Jonker, Michel Vierboom and Bert 't Hart – Biomedical Primate Research Centre BPRC, Rijswijk, The Netherlands IHCHM Philippens - 《Drug Discovery Today Disease Models》 被引量: 28发表: 2009年 What is the gold standard ...
this has been difficult, firstly because the data from humans is much more limited than what we can obtain in lab animals (we can modify lab animals, but not humans). It's also been tricky because the mathematical models to combine
Yan Riqiang and colleagues from the Cleveland Clinic Lerner Research Institute generated mice that gradually lost this enzyme as they grew older. These mice developed normally and appeared to remain perfectly healthy over time. "To our knowledge, this is the first observation of such a dramatic re...
in research compared to rodent models. For example, the U.K. Government’s Home Office classifies them as “Specially protected species” which can only be used for research cases in the absence of any other suitable model system21. The U.S. Government’s Animal Welfare Act was put in ...
The article discusses a research study on the treatment of Alzheimer's disease. Topics discussed include the role of appropriate dosage of drugs and animal models in the success of translating experimental drugs to humans, risk of aging in the preclinical studies of animal models, acceleration of ...
Journal of Neurorestoratology Dovepress open access to scientific and medical research Open Access Full Text Article Review Research progress in animal models and stem cell therapy for Alzheimer's disease This article was published in the following Dove Press journal: Journal of Neurorestoratology ...
Yuksel and Cansu Agca, researchers at the MU College of Veterinary Medicine, Mutant Mouse Resource and Research Center and Comparative Medicine Program, used rats experiencing surgically induced menopause to serve as Alzheimer's models at Discovery Ridge Research Park. After placing the rats in a spe...
systems to identify conserved mechanisms of toxicity or protection, however, the considerable evolutionary distance between these models and humans limits their utility. Mice have formed the backbone of AD research for a quarter century due to the powerful genetic toolkit available and comparatively ...