Yan Riqiang and colleagues from the Cleveland Clinic Lerner Research Institute generated mice that gradually lost this enzyme as they grew older. These mice developed normally and appeared to remain perfectly healthy over time. "To our knowledge, this is the first observation of such a dramatic re...
Leading the open access field for translational research into dementia and neurodegenerative diseases, Alzheimer's Research & Therapy is the major forum for ...
Now, in research at the University of Georgia, a cellular biologist and his colleagues have found that Hirano bodies may play a protective role in the progression ofneurodegenerative diseasessuch as Alzheimer's. And to find out why this may be happening, they have developed the world's firsttr...
systems to identify conserved mechanisms of toxicity or protection, however, the considerable evolutionary distance between these models and humans limits their utility. Mice have formed the backbone of AD research for a quarter century due to the powerful genetic toolkit available and comparatively ...
of current mouse models to replicate the real conditions of Alzheimer's disease and allow an understanding of the underlying mechanisms that lead to neurodegeneration. In fact, much of the research in Alzheimer's disease over the past decade may be flawed, as it was based on unrealistic models...
A major obstacle in Alzheimer’s disease (AD) research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy. Transgenic mice overexpressing amyloid precursor protein (App) gene manifest non-physiological and ectopic expression of APP and its fragmen...
In humans, the lag between development of thebeta-amyloid plaquesand thetau tanglesinsidebrain nerve cellscan be 10 to 15 years or more, Li says, but because the lifetime of a mouse is only two to three years, current animal models that successfully mimic the appearance of beta-amyloid pla...
Transgenic mice have been developed based on rare familial forms of AD and frontotemporal dementia, allowing investigators to test in detail the structural, functional, and behavioral consequences of AD-associated pathology. Here, we review work on transgenic AD models that investigate the degeneration ...
Underlying all these limitations is of course the fact that the research so far has only been established in mouse models. The entire field of Alzheimer's research is filled with studies that proved promising in animal models, yet could never be replicated in humans. ...