Background: Molecular and/or structural lesions in hippocampal neurons in Alzheimer's disease (AD) are thought to impair learning and memory (L & M), which depends on plasticity of dendritic spines. In AD, intracellular amyloid (icA尾) could damage synapses early in pathology, while Tau is ...
Inflammation contributes to neurodegeneration at later stages of AD, but it may also play a role in early disease pathogenesis. We found that before plaque deposition, amyloid precursor protein (APP)/presenilin 1 (PSEN1) transgenic mice (PSAPP mice), a well-characterized model of AD, exhibit ...
The DS model (Ts65Dn) is trisomic for the segment of murine chromosome 16, extending from the APP gene to the distal telomere. Results: In the hippocampus of 3 month old J20 mice, CBV values were higher than in controls, mainly in the subiculum (F=3.7, p=0.021) and in CA3 (F=...