Conclusions: Based on these findings, we propose that in AD mouse models, there is a very early detectable phase (present work), with a subsequent phase of cell dysfunction and thirdly, a well-documented later phase of neuronal loss. Since Ts65Dn mice develop some aspec ts of AD pathology...
We found that before plaque deposition, amyloid precursor protein (APP)/presenilin 1 (PSEN1) transgenic mice (PSAPP mice), a well-characterized model of AD, exhibit evidence of cerebrovascular inflammation. Expression of the endothelial cell-specific antigen MECA-32 (mouse endothelial cell antigen-32...