De Strooper, B. & Karran, E. The Cellular Phase of Alzheimer's Disease. Cell 164, 603-615 doi:10.1016/j.cell.2015.12.056 (2016).De Strooper B, Karran E (2016) The cellular phase of Alzheimer's disease. Cell 164:603-615.
Proteostatic Stress 是由于蛋白质变性或错误折叠引起的不溶性团聚物，无法被蛋白酶分解 而过度积聚, ...
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The efficacy of
De Strooper, B. & Karran, E. The cellular phase of Alzheimer’s disease. Cell 164, 603–615 (2016). PubMed Google Scholar Hardy, J. A. & Higgins, G. A. Alzheimer’s disease: the amyloid cascade hypothesis. Science 256, 184–185 (1992). CAS PubMed Google Scholar Karran, E. ...
Globally, 50 million people live with dementia, with Alzheimer disease (AD) being responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia-related neurodegeneration, changes in the timing or nature of the cellular hallmarks of normal ageing might be key to...
heimer's disease]]>Harmut Prats, Mar
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of the common late-onset forms of Alzheimer’s disease (AD). Accumulation of misfolded Aβ in the brain is believed to be a net result of imbalance between its production and removal. This in turn ma...
The Cellular Phase of Alzheimer’s Disease. Cell 2016, 164, 603–615. [Google Scholar] [CrossRef] [PubMed] [Green Version] Cervellati, C.; Wood, P.L.; Romani, A.; Valacchi, G.; Squerzanti, M.; Sanz, J.M.; Ortolani, B.; Zuliani, G. Oxidative challenge in Alzheimer’s ...
A poorer virus-specific T-cell response following influenza vaccination was observed in caregivers of Alzheimer’s disease patients compared to control individuals [224]. The aforementioned evidence suggests that psychological stress can contribute to LGCI and impair the normal response to infections and...
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