Non-human animal models characterized by the presence of A'beta' deposits similar to those found in individuals with Alzheimer's disease are also disclosed. Methods of screening test compositions for prophylactic or therapeutic activity by generating a non-human animal model having A'beta' deposits ...
Due to genetic differences, very few animals produce the human amyloid│(Aβ) peptide sequence that is necessary for aggregation and toxicity and believed to be central to Alzheimer's disease (AD) pathogenesis. Therefore, to study the disease, as well as factors that may reduce or exacerbate ...
Animal models for Alzheimer's disease and frontotemporal dementia: a perspective. ASN Neuro. 2009; 1 :e00019. pii.Gotz J, Gotz NN (2009) Animal models for Alzheimer’s disease and frontotemporal dementia: a perspective. ASN Neuro 1(4). doi: 10.1042/AN20090042...
Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E . Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J Cell Biol 1998; 143: 777–794. Article CAS PubMed PubMed...
Animal models constructed using pathogenic factors have significantly advanced drug development for Alzheimer’s disease (AD). These predominantly transgenic models, mainly in mice, replicate pathological phenotypes through gene mutations associated with
Alzheimer’s disease (AD) ranks as a leading cause of death among the progressive neurodegenerative diseases. It is the most common form of dementia found in the elderly population and is characterized by deterioration in mental function and abnormal behavior including wandering, irritability, and agg...
They not only model aspects of the human condition, but also simulate processes that occur in humans and hence provide insight into how disease is initiated and propagated. The present review discusses two prominent human neurodegenerative disorders, Alzheimer's disease and frontotemporal dementia. It ...
The following sections are included:IntroductionPathological Hallmarks of Alzheimer's DiseaseAmyloid precursor protein and amyloid β-peptideNeurofibrillary degeneration and tau pathologyAlzheimer's Disease Risk and Genetic FactorsAnimal ModelsNon-transgenic animal modelsNatural animal modelsModels related to cholin...
Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer’s disease experimental models Macarena de la Cueva , Desiree Antequera & Fernando Bartolome Article 16 June 2022 | Open Access Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabol...
Alzheimer’s disease (AD) is the most prevalent of all neurodegenerative disorders. Distinct protein inclusions, amyloid-β (Aβ) plaques, and neurofibrillary tangles (NFTs) characterize the AD brain. Several epidemiological studies have shown dissimilarities in AD when sex is considered, which has ...