Transgenic mouse models for Alzheimer's disease (AD) are now extensively used to understand the physiological and biochemical mechanisms of the disease as well as to discover new potential therapeutics. The identification of disease-causing mutations in proteins such as amyloid precursor protein (APP)...
Transgenic mouse models for Alzheimer's disease (AD) are now extensively used to understand the physiological and biochemical mechanisms of the disease as well as to discover new potential therapeutics. The identification of disease-causing mutations in proteins such as amyloid precursor protein (APP)...
Vascular dysfunction contributes to the progression and severity of Alzheimer’s disease (AD). Patients with AD also sustain larger infarctions after ischemic stroke; however, the responsible mechanisms are unknown. Pial collaterals are the primary source of protection in stroke. Unfortunately, natural ...
Research into the molecular mechanisms of Alzheimer disease (AD) continues to clarify important issues in aberrant protein processing while seeking to
Demographic changes will expand the number of senior citizens suffering from Alzheimer's disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset and progression of AD. AD mouse models may provide insights into mechanisms of
Oligomers of intracellular amyloid β protein (Aβ) are strongly cytotoxic and play crucial roles in synaptic transmission and cognitive function in Alzheimer's disease (AD). However, there is currently no AD model mouse in which to specifically analyze the function of Aβ oligomers only. We ...
Therefore, drugs that inhibit BACE1 are being developed as potential Alzheimer's disease treatments but, because BACE1 controls many important processes by cleaving proteins other than APP, these drugs could have serious side effects. Yan Riqiang and colleagues from the Cleveland Clinic Lerner Research...
The present review aimed to summarize insights regarding current AD research, and share perspectives for understanding glial function in the context of the pathogenesis of AD . 展开 关键词: Alzheimer's disease glial cell mouse model neuroimmune communication neuroinflammation ...
Background: Progressive memory loss and cognitive dysfunction are the obligate clinical features of Alzheimer disease. Genetically-modified mice have proven to be instrumental for elucidating the underlying pathogenetic mechansims leading to neurodegeneration and for identifying the molecular determinants underlyi...
Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in Alzheimer’s disease (AD) and AD mouse models. Extratelencephalic projection (ET) neurons in the PFC play a key role in short-term working memory, but the mechanism between ET neuronal dysfunction in the...