The dominant mechanism causing resistance is reactivated PI3K-AKT-mTOR signalling, but not other canonical signalling pathways. Deletion ofconferred resistance to PI3Kβi and AKTi through mTORC1. However, deletion ofanddrove specific PI3Kβi resistance through AKT. Conversely deletion of,,3 increased ...
IGF-1 中和抗体、NVP-AEW541、雷帕霉素阻断了 IGF-1R / AKT / mTORC1 信号通路,并减少了 LFCs 中 col-I 和 col-III 的产生。这些发现表明,循环机械应力促进 LFCs 分泌 IGF-1,通过 IGF-1R / AKT / mTORC1 信号通路诱...
我们的研究结果表明,Fatostatin处理通过抑制GBM中的AKT/mTORC1/GPX4信号通诱导GPX4介导的铁死亡。此外,Fatostatin诱导的细胞增殖和EMT的抑制也归因于AKT/mTORC1信号传导途径。为了克服BBB的阻碍,我们设计了装载Fatostatin的p28功能化PLGA纳米颗粒,并证明它们可以显著增加到达颅内肿瘤的药物剂量,并明显抑制肿瘤生长。
comPI3K - Akt - mTORC1 信号途径在脂质代谢中的作用杨 霞 1 韩春春 21. 成都农业科技职业学院,成都 6111302. 四川农业大学动物遗传育种所,雅安 625014摘 要 PI3K - AKT - mTORC1 信号途径在脂质代谢中起重要调控作用。PI3K - Akt - mTOR1 信号途径能够调节转录因子 SREBP -1 及其脂肪合成相关基因的表达来...
结论:谷氨酰胺代谢通过Akt-m TORC1通路调控巨噬细胞的活化,抑制谷氨酰胺代谢,减少M2型巨噬细胞活化,进而改善肾脏纤维化.第一部分谷氨酰胺代谢通过Akt-m TORC1调控巨噬细胞的活化目的:探讨谷氨酰胺代谢对巨噬细胞活化的作用和机制.方法:应用佛波脂(phorbol-12-myristate-13-acetate,PMA 100ng/ml)将U937细胞诱导...
【摘要】PI3K-AKT-mTORC1信号途径在细胞生长增殖中起重要调控作用,PI3K-Akt-mTOR1信号途径能够调节细胞周期相关蛋白基因的表达来调控细胞的增殖;同时,PI3K-Akt-mTOR1信号途径也能够调控细胞的生长和大小;PI3K-Akt-mTORC1信号途径的异常活化与肿瘤发生紧密相关.就PI3K-AKT-mTORC1信号途径在细胞生长增殖中的作用作一综述...
induced muscle atrophy, by promoting protein synthesis and inhibiting autophagy9. Others suggested that both autophagy5,10,11and PKB/Akt12,13,14,15are induced following denervation. Thus, the state and the role(s) of PKB/Akt-mTORC1 signaling and autophagy after nerve injury remain largely ...
Fig. 4: The PI3K-Akt-mTORC1 axis is upregulated in the m.3243 A > G mutant cells. aAnalysis of RNA-seq data from the patient fibroblasts by QIAGEN ingenuity pathway analysis (IPA) showed cell signalling pathways, which are enriched in cells carrying the m.3243 A > G mut...
Besides the actual GB tumor cells, GAMs can account for a rele- vant fraction of intratumoral cells and potentially influ- ence signal transduction of cancer cells or constitute a potential source of mTORC1 or AKT signaling. There- fore, we stained the samples for the pan-microglia and ...