The methyl- CpG -binding domain protein MBD4 enzymatically removes T or U from the mismatched sites and protects against tumorigenesis (Millar CB et al 2002 Science 297:403). Thymine DNA glycosylase (TDG) has similar repair function. Sodium bisulfite converts cytosine but not 5mC into uracil....
whereas the other leading to the undesired DNA/RNA degradation (Fig.1a)23. The protonated N3 nitrogen under acid conditions facilitates cytosine’s reaction with BS to give the C-BS adduct, which is converted to the U-BS adduct by deamination. Subsequent desulphonation of ...
物种:Broad 宿主:Sheep 抗体亚型:IgG 荧光染料:Purified 产品介绍 技术参数 相关产品 产品介绍 产品介绍 Sheep Anti 5-Methylcytosine (5-MeC) recognizes the methylated form of cytosine (C), an epigenetic modification catalyzed by DNA methyltransferases resulting in the attachment of a methyl group to carbo...
Valinluck, V., and Sowers, L.C. (2007). Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67, 946-950. Valinluck, V., Tsai, H.H., Rogstad, D.K., Burdzy, A., Bird, A., and Sowers, L.C. (2004). Oxidative...
29. Valinluck, V., and Sowers, L.C. (2007). Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67, 946-950. 30. Valinluck, V., Tsai, H.H., Rogstad, D.K., Burdzy, A., Bird, A., and Sowers, L.C. (2004...
5-formylcytosine 5hmC: 5-hydroxymethylcytosine 5mC: 5-methylcytosine AML: acute myeloid leukemia CIMP: CpG-island methylator phenotype CMML: chronic myelomonocytic leukemia DNMT: DNA methyltransferase HSC: hematopoietic stem cell IDH: isocitrate dehydrogenase MBD: methyl-CpG binding domain ...
We report that deamination coupled with 5-carboxyvinyl-2'-deoxyuridine-mediated photoligation causes the heat-induced transition of 5-methylcytosine to thymine with high selectivity and efficiency without any side reaction. The difference of deamination rate between 5-methylcytosine and cytosine is useful...
It was found as additional striking data that iterative TET-mediated oxidation of 5-hydroxymethylcytosine gives rise to 5-formylcytosine and 5-carboxylcytosine. This survey focuses on chemical and biochemical aspects of the enzymatic oxidation reactions of 5-methylcytosine that are likely to be ...
Man's yesterday may ne'er be like his morrow; Nought may endure but Mutabililty.Percy Bysshe Shelley (1816) MutabilityThe first hint that the cytosine-guanine (CpG) dinucleotide might constitute a hotspot for pathological mutations in the human genome ca
Summary Using conductivity detection, pulse radiolysis experiments showed that solvent protonation of the electron adducts of cytosine, 5-methyl cytosine a... A Hissung,CV Sonntag - 《International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine》 被引量: 19发表: 2009...