Deamination of 5-methylcytosines within cyclo- butane pyrimidine dimers is an important component of UVB muta- genesis. J Biol Chem. 2003;278:10314-10321. doi:10.1074/jbc. M212696200. PMID:12525487Lee, D. H. and Pfeifer, G. P. (2003) Deamination of 5-methylcytosines within cyclobutane ...
Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB Mutagenesis.Studies the mutagenic consequences that are associated with the deamination of cytosine within cyclobutane pyrimidine dimers (CPDs), in particular with respect to the involvement of 5-...
Transition of cytosine to thymine in CpG dinucleotides is the most frequent type of mutation in cancer. This increased mutability is commonly attributed to the spontaneous deamination of 5-methylcytosine (5mC), which is normally repaired by the base-exci
REVIEW Methylation-mediated deamination of 5-methylcytosine appears to give rise to mutations causing human inherited disease in CpNpG trinucleotides, as well as in CpG dinucleotides David N. Cooper,1* Matthew Mort,1 Peter D. Stenson,1 Edward V. Ball1 and Nadia A. Chuzhanova2 1Institute of...
5,6‐dihydro‐5‐methylcytosine5,6‐dihydrocytosinebisulfite conditiondeaminationThe discrimination of DNA methylation could make more complicated with the appearance of these minor bases. The conventional bisulfite sequencing faces with the tremendous challenge in the discrimination of DNA methylation. ...
Man's yesterday may ne'er be like his morrow; Nought may endure but Mutabililty.Percy Bysshe Shelley (1816) MutabilityThe first hint that the cytosine-guanine (CpG) dinucleotide might constitute a hotspot for pathological mutations in the human genome ca
This hypermutability is related to its role as the major site of cytosine methylation with the attendant risk of spontaneous deamination of 5-methylcytosine (5mC) to yield thymine. Cytosine methylation, however, also occurs in the context of CpNpG sites in the human genome, an unsurprising ...
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain Summary Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molec... Junjie U.,Guo,and,... - 《Cell》 被引量: ...
(1994) A simple assay for monitoring the mutagenic effects of 5-methylcytosine deamination in Escherichia coli. Mut. Res., 304, 181-185.A simple assay for monitoring the mutagenic effects of 5-methylcytosine deamination in Escherichia coli. Mutat. Res - Petropoulos, Vidmar, et al. - 1994...
5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we exploited the activity of apolipoprotein B mRNA-editing enzyme...