Ehrlich M, Zhang X-Y, Inamdar NM (1990) Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutation Res 238:277–286Ehrlich M, Zhang XY, Inamdar NM (1990) Spontaneous deamination of cytosine and 5-...
M. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutat. Res. 238(3), 277–286 (1990). 4. Kunz, C., Saito, Y. & Schar, P. DNA Repair in mammalian cells: Mismatched repair: Variations on a ...
1990). The proposed mechanism involves 5-methylation of cytosine by a methyltransferase and spontaneous deamination of 5-methylcytosine to thymine. This type of mutation was observed in 10 of the 12 families in this report (or in 13 of the 18 RTT families total). C→T or G→A (when the...
Spontaneous insertions have been shown to be important in the strongly polar inactivation of certain loci, but it is less important at other loci. Perhaps with continued study, the term "spontaneous mutagenesis" will be replaced by more specific terms such as 5-methylcytosine deamination mutagenesis...
(known as non-canonical or non-Watson–Crick base pair)1either endogenously during the biological processes like DNA replication2, recombination, spontaneous deamination, etc.3,4,5or exogenously by ionizing radiations such as X-rays and gamma rays2,6, and by the action of certain chemical ...
Studies the mechanisms of spontaneous human cancers. Proportions of cancer deaths attributed to various causes; Cancer as a genetic disorder of somatic cells; Background mutation rate of human cells; Deamination of 5-methylcytosine acts as an endogenous mutagen; DNA instability.Venitt...
Since spontaneous mutation frequency at cII is comparable in rat and mouse, the methylation status of CpG sequences in this gene also does not correlate with spontaneous frequency. We conclude that other mechanisms besides spontaneous deamination of 5-methylcytosine at CpG sites are driving spontaneous...
In this communication, the contribution of cytosine deamination to spontaneous mutagenesis in the lacI gene of E. coli was examined. In a wilde-type strain, 75% of the amber mutations recovered were G:C → A:T transition and 60% of these were at the 5-methylcytosine spontaneous hotspots ...