1990. Spontane- ous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutat. Res. 238:277-286.Ehrlich M, Zhang X-Y, Inamdar NM. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement ...
M. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues. Mutat. Res. 238(3), 277–286 (1990). 4. Kunz, C., Saito, Y. & Schar, P. DNA Repair in mammalian cells: Mismatched repair: Variations on a ...
1999). This discovery came as a surprise, since MECP2 would not appear to be a strong candidate for a primary brain disorder, because the protein is ubiquitously expressed, associated with 5-methylcytosine (5-mC)–rich heterochromatin, and potentially involved in global gene silencing (Nan et ...
Spontaneous insertions have been shown to be important in the strongly polar inactivation of certain loci, but it is less important at other loci. Perhaps with continued study, the term "spontaneous mutagenesis" will be replaced by more specific terms such as 5-methylcytosine deamination mutagenesis...
(known as non-canonical or non-Watson–Crick base pair)1either endogenously during the biological processes like DNA replication2, recombination, spontaneous deamination, etc.3,4,5or exogenously by ionizing radiations such as X-rays and gamma rays2,6, and by the action of certain chemical ...
Studies the mechanisms of spontaneous human cancers. Proportions of cancer deaths attributed to various causes; Cancer as a genetic disorder of somatic cells; Background mutation rate of human cells; Deamination of 5-methylcytosine acts as an endogenous mutagen; DNA instability.Venitt...
Since spontaneous mutations in transgenes have been attributed in part to deamination of 5-methylcytosine in CpG sequences, we have investigated the methylation status of the lacI transgene in bone marrow of BB rats and compared it to that present in other tissues including liver, spleen, and ...
In this communication, the contribution of cytosine deamination to spontaneous mutagenesis in the lacI gene of E. coli was examined. In a wilde-type strain, 75% of the amber mutations recovered were G:C → A:T transition and 60% of these were at the 5-methylcytosine spontaneous hotspots ...