Many microbial pathogens and toxins recognize animal cells via cell surface sialic acids (Sias) that are α2-3. or α2-8-linked to the underlying glycan chain. Human influenza A/B viruses are unusual in preferring α2-6-linked Sias, undergoing a switch from α2-3 linkage preference ...
BLAST analysis of the human and mouse genome sequence databases using the sequence of the human CMP-sialic acid:β-galactoside α-2,6-sialyltransferase cDN... Krzewinski-Recchi,Marie-Ange,Julien,... - 《European Journal of Biochemistry》 被引量: 90发表: 2003年 The pattern of glycosyl- and...
Sialyltransferases which add sialic acid with α2,3-, α2,6-, or α2,8-linkages contribute to the terminal of carbohydrate structures and functions of cell surface molecules including glycolipids and glycoproteins (Tsuji et al. 1996; Harduin-Lepers et al. 2001; Audry et al. 2011). Glycans...
Neuraminidase Au Alpha-(2-3,6,8,9),α(2-3,6,8,9) Sialidase cleaves all non-reducing terminal sialic acid residues from complex carbohydrates and glycoproteins. In addition, the enzyme will cleave branched sialic acids (linked to an internal residue). Recombinant from Arthrobacter ureafaciens ...
andalpha-2,6-linkedsialicacid.Alsobindsdisialogangliosides(disialogalactosylgloboside,disialyl lactotetraosylceramideanddisialylGalNAclactotetraoslylceramide).Thesialicacidrecognitionsitemaybe maskedbycisinteractionswithsialicacidsonthesamecellsurface.Intheimmuneresponse,mayactasan inhibitoryreceptoruponligandinducedty...
Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognit... CD22 beta is a glycoprotein found on the surface of B cells during restricted stages of development. It is believed to play a role...
They found that there is more fucosylated and less sialylated complex glycans present in HEK-expressed RBD proteins, and that removal of only sialic acids or terminal fucoses enhances antibody reactivity while removal of all glycans diminishes antibody reactivity. We also observed high abundance of ...
We next created a model of TMPRSS2 in complex with AAT (Figs.6andS3). Excellent alignment between the P1 residue of the reactive center loop (RCL) of AAT and the TMPRSS2 inhibitor nafamostat indicates that AAT is docked with TMPRSS2 in an inhibition-competent orientation (Fig.6B,C). ...
sialic acidsDistinct structural changes of the alpha 2,3/alpha 2,6-sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of ...
[solution] cell strain and people α -2,3- sialyltransferases are embodied in the mode of the both sides of FSH, in conjunction with α 2,3 and α 2,6 sialic acids the two mixing mode it is glycosylated) recombinant FSH. In Fig. 1コッティンガム,イアン...