Glycans with α2,3-linked sialic acids present on cell surface are known as receptors of viruses such as influenza viruses and target molecules of siglecs, which contain an immunoglobulin domain with lectin act
Alpha-2, 3-STs mediate the sialic acid with an α-2, 3-linkage to the terminal Gal residues (ST3Gal I–VI).5 Changes in the expression level of specific α-2, 3-STs have been observed in several tumors. ST3Gal I or II was up- regulated in human bladder cancer tissues or renal ...
We found that immobilized MAL interacts with high affinity with complex-type tri- and tetraantennary Asn-linked oligosaccharides containing outer sialic acid residues linked alpha 2,3 to penultimate galactose residues. Glycopeptides containing sialic acid linked only alpha 2,6 to penultimate galactose ...
Using specific sialic acid-binding lectins, such as Maackia amurensis lectin- II (MAL-II) for alpha-2,3-sialylated glycan and Sambucus nigra agglutinin (SNA) for alpha-2,6-sialylated glycan, we tried to explore the GSC-associated sialic acid-modified glycans and their roles....
FunctionPutativeadhesionmoleculethatmediatessialic-aciddependentbindingtocells.Preferentiallybindstoalpha-2,3-andalpha-2,6-linkedsialicacid.Alsobindsdis..
This finding prompted us to re-examine the structure of the LOS from the L1 immunotype, which revealed the presence of sialic acid on the terminal alpha-linked galactose. Oligosaccharides derived from the LOS were shown to be sialylated by composition and methylation analysis, mass spectrometry ...
Neuraminidase Au Alpha-(2-3,6,8,9),α(2-3,6,8,9) Sialidase cleaves all non-reducing terminal sialic acid residues from complex carbohydrates and glycoproteins. In addition, the enzyme will cleave branched sialic acids (linked to an internal residue). ...
A major flagellum sialoglycoprotein in sea urchin sperm contains a novel polysialic acid, an alpha2,9-linked poly- N -acetylneuraminic acid chain, ... M Shinji,S Chihiro,K Shigeyuki,... - 《Glycobiology》 被引量: 79发表: 2004年 Co-expression of two distinct polysialic acids, α2,8-...
Fig. 3 The number of detected N-glycans at 21 conventional sequons (A) and the relative abundance of fucosylated (Fuc) (B) and sialylated (SA) glycans (C) Full size image Many N-glycans contain sialic acid and fucose groups. These sialylated and fucosylated glycoforms implicated a range of...
Here we show that MuV preferentially uses a trisaccharide containing 伪2,3-linked sialic acid in unbranched sugar chains as a receptor. Crystal structures of the MuV attachment protein hemagglutinin-neuraminidase (MuV-HN) alone and in complex with the......