The present invention discloses a modified sialic acid N- (α- (2 → 6)) - D- amino pyranose derivatives and synthetic methods and applications. 本发明以D-氨基半乳糖(葡萄糖)和唾液酸为原料,合成了式(I)所示的唾液酸(α-(2→6))-D-氨基吡喃糖衍生物,并将其与载体蛋白质或多肽进行偶联得到了...
6 months, -20 to -70 °C under sterile conditions after reconstitution. Background: ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5 Gangliosides are acidic glycosphingolipids that contain one or more sialic acid residues (1). They are abundant in the nervous system, where ...
In IMIM-PC-1 cultures, alpha2,3 sialic acid was detected mainly in the apical membrane, whereas alpha2,6 sialic acid was more abundant in the basolateral domain of polarized cells. In these cells, treatment with GalNAc-O-benzyl led to reduced alpha2,3 levels and to an increase and ...
Interestingly, the mature form of UT-A3 glycan contains significant amounts of sialic acid. We explored the enzymes responsible for directing UT-A3 sialylation. Sialyltransferase ST6GalI, but not ST3GalIV, catabolizes UT-A3 伪2,6-sialylation. Activation of protein kinase C (PKC) by PDB ...
ST6GalNAc-II is a CMP-sialic acid - N-acetylgalactosaminide α2-6-sialyltransferase (GalNAcα2-6-sialyltransferase) - i.e., transfers sialic acid from CMP-sialic acid (CMP-Sia) to the N-acetylgalactosamine residues of glycoconjugates through an α2,6-linkage. Like other sialyltransferases, ...
Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a ... The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections mandates close monitoring for resistant variants. Cultu...
SiaBb2 liberated sialic acids from sialyloligosaccharides, gangliosides, glycoproteins and colominic acid; however, the linkage preference of the enzyme was remarkably biased toward the α2,3-linkage rather than α2,6- and α2,8-linkages. Expression of siabb2 in B. longum 105-A, which has ...
These results indicate that alpha 2,6-ST expression is a critical regulatory step in the formation of the Ags that are recognized by these mAb, and that an alpha 2,6-linked sialic acid residue is an essential component of each Ag. Thus, expression of a single ST can result in the ...
Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a ... The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections mandates close monitoring for resistant variants. Cultu...
A novel type of sugar nucleotide, containing 1 rather than 2 phosphate residues, was isolated from Escherichia coli K-235. The nucleotide was shown to be cytidine 5'-monophospho- N -acetylneuraminic acid in which the sialic acid was gly... DG Comb,DR Watson,S Roseman - 《Journal of Bio...