The present invention discloses a modified sialic acid N- (α- (2 → 6)) - D- amino pyranose derivatives and synthetic methods and applications. 本发明以D-氨基半乳糖(葡萄糖)和唾液酸为原料,合成了式(I)所示的唾液酸(α-(2→6))-D-氨基吡喃糖衍生物,并将其与载体蛋白质或多肽进行偶联得到了...
In Caco-2, HT-29 5M12, and MCF-7 cells, which express sialic acid mainly in one type of linkage, the majority of the signal was observed in the apical membrane. In cells that bound both lectins, alpha2,3 sialic acid was distributed apically, whereas alpha2,6 sialic acid showed a ...
Background: ST6 GalNAc alpha-2,6-sialyltransferaseV/ST6GALNAC5 Gangliosides are acidic glycosphingolipids that contain one or more sialic acid residues (1). They are abundant in the nervous system, where they play crucial modulatory roles in cellular recognition, interaction, adhesi...
Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a ... The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections mandates close monitoring for resistant variants. Cultu...
ST6GalNAc-II is a CMP-sialic acid - N-acetylgalactosaminide α2-6-sialyltransferase (GalNAcα2-6-sialyltransferase) - i.e., transfers sialic acid from CMP-sialic acid (CMP-Sia) to the N-acetylgalactosamine residues of glycoconjugates through an α2,6-linkage. Like other sialyltransferases, ...
Interestingly, the mature form of UT-A3 glycan contains significant amounts of sialic acid. We explored the enzymes responsible for directing UT-A3 sialylation. Sialyltransferase ST6GalI, but not ST3GalIV, catabolizes UT-A3 伪2,6-sialylation. Activation of protein kinase C (PKC) by PDB ...
These results indicate that alpha 2,6-ST expression is a critical regulatory step in the formation of the Ags that are recognized by these mAb, and that an alpha 2,6-linked sialic acid residue is an essential component of each Ag. Thus, expression of a single ST can result in the ...
Sialyltransferases which add sialic acid with α2,3-, α2,6-, or α2,8-linkages contribute to the terminal of carbohydrate structures and functions of cell surface molecules including glycolipids and glycoproteins (Tsuji et al. 1996; Harduin-Lepers et al. 2001; Audry et al. 2011). Glycans...
Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha 2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and ...
Product Name:alpha-(2-9)-disialic acid Synonyms: alpha-(2-9)-disialic acid Reaxys ID: 5716030 CAS:114474-59-8 MF:C22H34K2N2O17 MW:676.70516 EINECS: Mol File:114474-59-8.mol Browse by Nationality 114474-59-8 Suppliers >Global suppliers EnquiryPlease select the suppliers Recommend You...