Metabolic changes in sialic acid synthesis pathway in GNE‐myopathy model mice with long‐term sialic acid treatmentGNE-myopathy is an autosomal recessive disorder characterized by muscle atrophy, distal muscle
Ongoing work suggests a sialic acid synthesis pathway inSeveno, MartialMuriel, BaradorPaccalet, ThomasGomord, VeroniquePatrice, LerougeFaye, Loïc
31. Here, using transcriptomic data and tissue stainings, we showed that PDAC is characterised by an increased sialylation. Increased sialylation was facilitated by enhanced expression of different enzymes involved in the synthesis of the sugar donor (Sialic acid-CMP), and also ...
In this context, we have investigated the synthesis of N -acetylneuraminic acid (Neu5Ac) in the cytosol of plants by either the re-routing of the endogenous 3-deoxy- d - manno -2-octulosonic acid (Kdo) biosynthetic pathway or the expression of microbial Neu5Ac-synthesizing enzymes. In ...
2). Therefore, the potential of sialic acid (Neu5Ac) synthesis by PAO was assessed by means of in silico genome analysis. As shown in Fig. 5, in the metabolic pathway of Neu5Ac, GlcNAc-6-phosphate is epimerized to ManNAc-6-phosphate by GlcNAc-6-P 2-epimerase. The phosphate groups ...
Biosynthesis pathway of sialylation Sialic acid metabolism is regulated by sialyltransferases and sialidases. Sialyltransferases, located on the type II membrane protein of the Golgi apparatus, catalyze the transfer of sialic acid from a glycosyl donor CMP-Neu5Ac to the terminal positions of oligosacch...
UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE): a master regulator of sialic acid synthesis Top. Curr. Chem., 366 (2015), pp. 97-137 View in ScopusGoogle Scholar [41] B. Weinhold, R. Gerardy-Schahn, A. Münster-Kühnel Cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS) Handb...
Biosynthesis pathway of sialylation Sialic acid metabolism is regulated by sialyltransferases and sialidases. Sialyltransferases, located on the type II membrane protein of the Golgi apparatus, catalyze the transfer of sialic acid from a glycosyl donor CMP-Neu5Ac to the terminal positions of oligosacch...
The compartmentalization of cytidine 5′-monophosphate (CMP)-sialic acid synthesis in the cell nucleus (for review Kean 1991; Münster et al. 1998) and its metabolism in the lumen of the Golgi apparatus demonstrates that a system that transports the...
Unnatural analogues of sialic acid can be delivered to mammalian cell surfaces through the metabolic transformation of unnatural N-acetylmannosamine (ManNAc) derivatives. In previous studies, mannosamine analogues bearing simple N-acyl groups up to five carbon atoms in length were recognized as ...