Sialic acid synthase encoded by the neuB gene of Escherichia coli catalyzes the condensation of N-acetylmannosamine and phosphoenolpyruvate to form N-acetylneuraminic acid. This report demonstrates the first structural information on sialic acid synthase by CD, MALDI-TOF, and chemical cross-linking ...
在生物体中,唾液酸的活化形式为CMP - 唾液酸,其合成路径如下: 唾液酸生成:葡萄糖经多步代谢转化为 N - 乙酰甘露糖胺(ManNAc),后者与磷酸烯醇式丙酮酸(PEP)在唾液酸合成酶(Sialic Acid Synthase, SAS)催化下生成 N - 乙酰神经氨酸(Neu5Ac)。 胞苷酸化:Neu5Ac 在 CMP - 唾液酸合成酶(CMP-Sialic Acid ...
Sialic acids have key roles in intercellular signaling through specific ligands: sialic acid-binding immunoglobulin-like lectins (SIGLECs) and selectins. The interaction between these molecules is facilitated by a salt bridge between arginine and the carboxyl group of Neu5Ac [21]. Upon sialic acid ...
et al. Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci. 15, 1010–1016 (2006). Article CAS Google Scholar Rajavel, K.S. & Neufeld, E.F. Nonsense-mediated decay of human HEXA mRNA. Mol. Cell. Biol. 21, 5512–5519 (2001). Article CAS ...
Sialic Acid Clostridium Perfringens Trypanosoma Cruzi Polysialic Acid Neuraminic Acid These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. ...
Sialic acidrecognizingimmunoglobulin(Ig)-superfamilylectins(Siglecs) are a major subset of the I-type lectins. The latter are defined as animal proteins other than antibodies or T-cell receptors that can mediate carbohydrate (glycan) recognition via Ig-like domains.Siglecsshare characteristic amino-term...
E Comparison of transcriptional expression of the sialic acid-binding Ig-like lectin family among three SiaM clusters. The lower panel shows the cell-specific locations of the sialic acid-binding Ig-like lectin family. F Comparison of the relative levels of T-cell co-inhibition, T-cell ...
(NA), another glycoprotein on the influenza virus surface, facilitates the cleavage of HA-sialic acid bonds [180], thereby enhancing viral infectivity. NA cleaves the links between the virus and heavily sialylated mucins in the upper respiratory system [184], which act as decoys. Like HA, NA...
实验用CMP-唾液酸合成酶;CMP-sialic acid synthetase (NmCSS) E. coli Recombinant CMP-Sialic acid synthetase from Neisseria meningitides E.C. No.: 2.7.7.43 MW: 26 kDa Purity: min 95% by SDS-PAGE Unit Def
1) Sialic acid synthase 唾液酸合成酶 例句>> 2) CMP-NeuAc synthetase CMP-唾液酸合成酶 3) polysialytransferases 多唾液酸合酶 1. Objective To study the changes of neural cell adhesion molecule(NCAM) andpolysialytransferases(STX) mRNA expression and NCAM protein expression after whole-body exposur...