We report here a detailed analysis of globin gene switching in these early human erythroblasts as a function of time of co-culture of the hESCs on the FH-B-hTERT cells.Caihong QiuEmmanuel OlivierEric E. BouhassiraBlood cells, molecules and diseases...
giobin gene dupiication and identify the reguiatory eiements present in the giobin genes,we cioned the !- and "- giobin genes of P. crocea and investigated the two giobin genes arrangement. Linkage anaiysis reveaied that the !- and "- giobin genes were orien- ted head-to-head rei...
The beta-thalassemia is associated with abnormality in beta-globin gene, leading to imbalanced synthesis of alpha-/beta-globin chains. Consequently, the excessive free alpha-globin chains precipitate to the erythrocyte membrane, resulting in hemolytic anemia. We have explored post-transcriptional strategie...
We have studied the transient expression of a cloned rabbit hemoglobin β1 gene after its introduction into HeLa cells. Two and one-half days after transfection using the calcium phosphate technique, we extracted RNA from the entire cell population and analyzed it by the S1 nuclease hybridization ...
The beta-globin gene cluster is located on chromosome 11. SNPs database was published by Hap Map Project. Here, novel tag SNPs on beta -globin gene cluster in Chinese Han population was reported on using Haploview 4.2. The haplotype block and LD analysis showed three blocks that were ...
网络类β珠蛋白基因簇 网络释义 1. 类β珠蛋白基因簇 gene-英汉词典... ...beta like globin gene cluster[医]类β珠蛋白基因簇bithorax comples gene [医]果蝇的双胸复合基因 ... www.fastdict.net|基于 1 个网页
1. High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster [J] . Lv X, Xu DD, Liu DP, Biochemistry and Cell Biology . 2002,第6期 机译:高迁移率族蛋白2可能参与β-珠蛋白基因簇的基因座控制区调控 2. Beta-globin gene swit...
To assess the relationship between being beta globin gene carrier and developing insulin resistance.This study was conducted on 164 subjects including 82 healthy ones and 82 patients with beta thalassemia minor (microcytosis (MCV <80 fl) and hypochromia (MCH <25 pg) and HbA2 ≥ 3.5% using HP...
Generally, nonsense codons 50 bp or more upstream of the 3'-most intron of the human beta-globin gene reduce mRNA abundance. In contrast, dominantly inherited beta-thalassemia is frequently associated with nonsense mutations in the last exon. In this work, murine erythroleukemia (MEL) cells were...
Article: Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF