β-珠蛋白基因(β-Globin gene ) 多态性分析 1.1实验目的 制备人染色体DNA以及测定DNA的浓度和纯度。1.2 实验原理 1. 人体内各种组织细胞的染色体DNA都携带有全身的遗传信息。因此，可以从口腔粘膜脱落细胞中制备人的染色体DNA，然后分析目的基因的结构及多态性。 2. 基因组DNA在生物体内是与蛋白质形成复合物的...
of the b-Globin Gene LocusChakalova, LyubomiraCarter, DavidDebrand, EmmanuelGoyenechea, BeatrizHorton, AliceMiles, JoanneOsborne, Cameron
The distribution of a nucleotide polymorphism in intron 2 of the β-globin gene (IVS-2 nt 666 C > T was examined in populations in southern Germany and Cameroon. The allelic frequencies were 0.86 for T and 0.14 for C in southern Germany and 0.87 for T and 0.13 for C in Cameroon, resp...
Previous experiments have demonstrated that the human β -globin gene is correctly regulated in transgenic mice. The β -globin gene is not expressed in yo... RR Behringer,RE Hammer,RL Brinster,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量...
dominantly inherited b thalassaemia intermedia caused by a new single nucleotide deletion in exon 2 of the b globin gene: hb morgantown (b91 ctg.cg) et al.Dominantly inherited beta thalassaemiaintermedia caused by a new single nucleotide deletion in exon 2 of the beta globingene: Hb morgantown...
Addgene product type : cDNA product name : pSPORT1[NheI/glGFP/bglobin3'-UTR/Ins2] catalog : 74101 more info or order: Addgene product webpage citations: 1 Reference Wang C, Szaro B. A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xen...
Gene Ther. 6 , 442–447.Narayanan K, Williamson R, Zhang Y, Stewart AF, Ioannou PA. Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system. Gene Therapy 1999; 6: 442-447....
Human Genomics (2020) 14:39 https://doi.org/10.1186/s40246-020-00283-3 PRIMARY RESEARCH Open Access Mild dyserythropoiesis and β-like globin gene expression imbalance due to the loss of histone chaperone ASF1B Petros Papadopoulos1,2* , Athanassia Kafasi3, Iris M. De Cuyper3, Vilma ...
Structural polymorphism exhibited by a quasipalindrome present in the locus control region (LCR) of the human 尾-globin gene cluster Kukreti, Structural polymorphism exhibited by a quasi- palindrome present in the locus control region (LCR) of the human b-globin gene cluster. Nucleic ... M Kaus...
Severe Hb S/β-thal with a T C substitution in the donor splice site of the first intron of the β-globin gene 来自 Wiley 喜欢 0 阅读量: 28 作者:JM Gonzalez-Redondo,TA Stoming,F Kutlar,A Kutlar,THJ Huisman 摘要: Through direct sequencing and dot-blot analyses with synthetic ...