首页/癌基因/FGFR1/ ZNF198-FGFR1 FGFR1基因所编码的蛋白质是属于成纤维细胞生长因子受体(FGFR)家族成员之一,目前已确定了四种由FGFRs, 即FGFR1、FGFR2、FGFR3和FGFR4。FGFR1是一种跨膜蛋白质,属于受体酪氨酸激酶,当FGF与FGFR1胞外段结合后,受体细胞内段酪氨酸激酶活性区首先发生自身磷酸化,然后使受体靶蛋白发生反...
ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain. Blood 2000;96:699-704. [PubMed: 10887137]ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain. Xiao S,McCarthy JG,Aster JC,et al. Blood . 2000...
We used oligonucleotide microarrays to compare the gene-expression profiles between HEK-293 cells that stably express either the ZNF198/FGFR1 chimeric protein or the wild-type ZNF198 gene. Expression of the plasminogen activator inhibitor-2 (PAI-2/SERPINB2) was highly increased in cells expressing ...
本发明公开一种用于检测8p11骨髓增殖综合征(EMS)患者中ZNF198FGFR1融合基因的试剂盒,其包括扩增ZNF198FGFR1融合基因的引物和探针,及内参基因ABL的引物和探针.本发明可快速检测EMS患者体内是否存在ZNF198FGFR1融合基因及其表达量的多少.利用本发明完成的检测结果准确,灵敏,可辅助诊断骨髓增殖综合征,确定融合类型,对在疾病...
ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5[J].Neoplasia,1999,(04):349-355.doi:10.1038/sj.neo.7900035.Smedley D, Demiroglu A, bdul-Rauf M, Heath C, Cooper C, Shipley J, et al. ZNF198-FGFR1 ...
Trimaldi J, Carballido EM, Bowers JW et al. B-Lymph- oblastic Leukemia/Lymphoma Associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : Rare Case and Review of the Literature. Acta Haematol 2013;130:127-134.Trimaldi J, Carballido EM, Bowers JW, et al. B-lympho- blastic ...
Ri Zhangchinese medical journalChao H, Zhou M, Zhang R. A case with ZNF198-FGFR1 gene rearrangement presenting as acute eosinophil myeloid leukemia. Chin Med J. 2015;128(1):131-132. doi:10.4103/0366-6999.147863. PubMed PMID: 25563327; PubMed Central PMCID: PMCPmc4837809. eng....
K. (2009) Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS. Proteomics 9, 3979-3988Kasyapa C, Gu TL, Nagarajan L, et al. Phosphorylation of the SSBP2 and ABL proteins by ...
Zhang RiChangzhou中华医学杂志(英文版)Chao H, Zhou M, Zhang R. A case with ZNF198-FGFR1 gene rearrangement presenting as acute eosinophil myeloid leukemia. Chin Med J. 2015;128(1):131-132. doi:10.4103/0366-6999.147863. PubMed PMID: 25563327; PubMed Central PMCID: PMCPmc4837809. eng....
K. (2009) Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS. Proteomics 9, 3979-3988Kasyapa C, Gu TL, Nagarajan L, et al. Phosphorylation of the SSBP2 and ABL proteins by ...