Such an effect was not observed for BA/F3 cells lacking FGFR1. Therefore, cyclic peptide F8 can act as a FGF1-FGFR1 interaction antagonist, and may be suitable for further development for potential use in therapies against FGFR1-expressing cancer cells....
resembles that of FGF1-deficient mice, which upon feeding with HFD show an increased number of very large adipocyte, decreased insulin sensitivity, increased inflammation and a restriction of the phenotype to the visceral adipose tissue32. We also identified FGFR1 as the FGF-receptor subtype on ...
Fibroblast Growth Factors 1-2 (FGF1-2) stimulate tail regeneration in lizards and therefore the distribution of their receptors, FGFR1-2, in the regenerating tail of the lizard. Podarcis muralis has been studied using immunofluorescence and western blotting. Immunoreactive protein bands at 15-16kDa...
Our findings provide insight into possible mechanisms underlying the pathogenesis of phosphaturic mesenchymal tumor and imply a central role of the FGF1-FGFR1 signaling pathway. The novel FN1–FGF1 protein is expected to be secreted and serves as a ligand that binds and activates FGFR1 to achieve...
采用四甲基噻唑蓝法检测细胞存活率,伤口愈合实验和Transwell分别检测乳腺癌细胞迁移,侵袭能力,实时荧光定量聚合酶链反应测定FGFR1和FGFR2的mRNA表达,Western blotting法检测FGF1和FGFR1蛋白表达水平.使用GEO数据库分析FGFR1和FGFR2的表达对乳腺癌患者总生存期和无病生存期的影响.结果结果1000μg/mL的LTN与2...
Opening of Piezo1 in mature adipocytes causes the release of the adipogenic fibroblast growth factor 1 (FGF1), which induces adipocyte precursor differentiation through activation of the FGF-receptor-1. These data identify a central feed-back mechanism by which mature adipocytes control adipogenesis ...
The present disclosure provides FGF1 mutant proteins, which selectively bind to/activate FGFR1b. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed FGF1 mutants to reduce blood glucose in a ...
纖維母細胞生長因子接受器1大鼠腎上腺髓質嗜鉻細胞瘤神經軸突生長HASH(0x1a744990HASH(0x1a744a30HASH(0x1a744ad0) SH2B1βFGF1FGFR1纖維母細胞生長因子一 (fibroblast growth factor 1, FGF1) 在細胞的生長發育中是重要的生長因子.從基因層面的相關研究得知,纖維母細胞生長因子之訊息傳遞與其調控之基因表現在胚胎...
Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol 177, 2379-2386 (2010).Tomlinson DC, Knowles MA. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased ...
Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer - AbstractAdministrator