通过激活FGFR1受体并触发ERK1/2信号途径,FGF21展现出了显著的心肌保护作用。首先,我们观察到FGF21在细胞内能够促进蛋白质的正确折叠和降解。内质网是细胞内蛋白质合成和折叠的主要场所,当内质网面临应激时,蛋白质的折叠和降解过程会受到影响,导致未折叠或错误折叠的蛋白质积累。FGF21的介入,似乎能够协助这些蛋白质找到...
Recent research has revealed that FGF21 could play an important role in cardiac pathological remodeling effects and prevention of cardiomyopathy; however, the underlying mechanism remains largely unknown. This study aimed to determine the mechanism underlying the cardioprotective effects of FGF21. We ...
实验结果如下:毛囊形成期:(1)IHC-P实验结果显示:FGF21在E13天时表达于基底层细胞中,E14天表达于基底层和毛芽,E17、E18天主要表达在毛乳头;FGFR1在E13天主要表达于表皮和基底层中,E14天表达于表皮和毛芽,E15、E16天表达在表皮和毛钉中,E17、E18天表达于表皮及毛基质中;FGFR2在E13至E18天主要表达在表皮和...
摘要 目的探究开心解郁丸(KJP)对抑郁症模型大鼠肝组织过氧化物酶体增殖物激活受体α(PPARα)、血清及海马组织成纤维生长因子21(FGF21)和海马组织成纤维生长因子受体1(FGFR1)的影响。方法通过慢性不可预知温和应激...展开更多 Objective To explore the effects of Kaixin Jieyu Pill(KJP)on peroxisome proliferator-...
Objective To investigate the mechanism of the fibroblast growth factor 21 ( FGF21) / β-klotho / fibroblast growth factor type 1 receptor (FGFR1) pathway in brain injury of type 2 diabetes mellitus (T2DM) model rats with focal cerebral ischemia. Methods SD rats were fed a high fat diet and...
the in vitro cellular experiments demonstrated that FGF21 exerted a protective effect against glutamate-induced cytotoxicity and promoted cell differentiation and growth. Then, in wild-type and FGF21−/−mice, exogenous FGF21 promoted FGFR1-5-HT1AR heteromers formation in the CA3 anddentate gyrus...
Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite coreceptor βKlotho. ...
These results not only demonstrate the essential roles of FGFR1c and -Klotho in mediating the metabolic effects of FGF21, they also describe a first bispecific activator of this unique receptor complex and provide validation for a novel therapeutic approach to target this potentially important pathway...
而腹腔注射FGF-21可以通过降低眼内炎症水平来延缓干性AMD发生发展.(4)利用FGFR1垂钓出6种小分子,其中1种与FGFR1具有特异性亲和力,细胞培养显示该小分子能够促进FGFR1磷酸化,并体现出抗氧化和抗炎的生物学活性.结论:本研究以上结果表明,Fgf-21缺失能够增强眼内炎症反应进而促进干性AMD的发生发展,腹腔注射FGF-21能够抑制...