通过激活FGFR1受体并触发ERK1/2信号途径,FGF21展现出了显著的心肌保护作用。首先,我们观察到FGF21在细胞内能够促进蛋白质的正确折叠和降解。内质网是细胞内蛋白质合成和折叠的主要场所,当内质网面临应激时,蛋白质的折叠和降解过程会受到影响,导致未折叠或错误折叠的蛋白质积累。FGF21的介入,似乎能够协助这些蛋白质找到...
Recent research has revealed that FGF21 could play an important role in cardiac pathological remodeling effects and prevention of cardiomyopathy; however, the underlying mechanism remains largely unknown. This study aimed to determine the mechanism underlying the cardioprotective effects of FGF21. We ...
Coordinately, FGF21 exerted similar influences in the hippocampi of IBA-induced neurological injury mice or combined stress-exposed mice. Besides, FGF21 treatment activated the phosphorylation of FGFR1 and elevated the expression of synaptophysin in these mice with neurological injury or combined stress e...
通过激活FGFR1-ERK1/2信号途径,FGF21能够有效地减轻心肌细胞内质网应激损伤,为心血管疾病的治疗提供了新的方向和理论依据。未来,我们可以进一步研究FGF21在心血管疾病中的具体应用及作用机制,以期为临床治疗提供更多支持。在深入理解FGF21通过FGFR1-ERK1/2信号途径减少心肌细胞内质网应激损伤的过程中,我们可以进一步探索其...
而腹腔注射FGF-21可以通过降低眼内炎症水平来延缓干性AMD发生发展.(4)利用FGFR1垂钓出6种小分子,其中1种与FGFR1具有特异性亲和力,细胞培养显示该小分子能够促进FGFR1磷酸化,并体现出抗氧化和抗炎的生物学活性.结论:本研究以上结果表明,Fgf-21缺失能够增强眼内炎症反应进而促进干性AMD的发生发展,腹腔注射FGF-21能够抑制...
(P0.05,P0.01),TUNEL阳性颗粒数目显著减少(P0.01).结论:心梗可诱导肝脏发生内质网应激,线粒体自噬流异常和肝细胞凋亡,导致肝损伤.有氧运动干预可抑制心梗小鼠肝脏ALCAT1表达,激活FGF21-FGFR1/β-Klotho-PI3K/AKT通路,抑制内质网应激和线粒体自噬流异常,减轻肝细胞凋亡,改善肝功能.推测FGF21和ALCAT1可能是有氧...
In contrast, FGFR1 inhibitor PD173074 partially reversed the rhFGF21-induced therapeutic effects. Overall, this work revealed that rhFGF21 activates the FGFR1/尾-Klotho pathway to decrease ferroptosis of nerve cells, suggesting that FGF21 could be a new therapeutic target for SCI neurological ...
Knockdown of FGFR1 and p38 genes weakened SFN-reduced lipid deposition in FFAs-treated HepG2 cells. SFN administration in combination with rmFGF21 (1.5mg/kg, i.p., every other day) for 3 weeks further suppressed hepatic steatosis in NAFLD mice. In conclusion, SFN ameliorates lipid metabolism...
The present invention provides agonists of FGF21 signaling. In particular, the present invention provides FGF21 receptor (FGF21R) agonists that are capable of simultaneously binding 尾Klotho (KLB) and/or FGFR1c to mimic the signaling activity of FGF21. The present invention also provides anti-...
梗死体积缩小,神经功能改善.侧脑室注射FGFR1抑制剂SU5402可下调缺血半暗带区PI3K,p-Akt,Occludin,Claudin-5和ZO-1的表达,减弱血管再通治疗对MCAO大鼠神经功能转归的有利作用.结论:MCAO后第3天的血管再通治疗增加缺血半暗带内源性FGF21的表达,并可通过激活FGFR1/PI3K/Akt通路减轻缺血半暗带BB...