河北大学的 Wang等近期在Oncogenesis上发表文章[1],报道了他们近期在胃癌细胞中的研究成果,证实LGR5通过激活Wnt/β-Catenin信号通路推动了胃癌演进。他们发现LGR5的过表达和敲减分别上调和下调了胃癌细胞的增殖、迁移和侵袭,而C59(Wnt抑制剂)和Wnt3a(Wnt激活剂)的处理可部分拮抗被LGR5表达影响的胃癌细胞行为。这反映...
3.Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer.Nat Rev Cancer2013; 13:11-26. 4.Jamieson C, Sharma M, Henderson BR. Targeting the β-catenin nuclear transport pathway in cancer.Semin Cancer...
cancersmall moleculesbiologicsinhibitorsβ-cateninAxinAPCtumour suppressoroncogeneCanonical Wnt/尾-catenin signalling is a highly conserved pathway that plays an essential role during embryonic development. In the adult, the Wnt pathway regulates stem cell maintenance and tissue homeostasis. Inappropriate ...
CTNNB1-independent WNT signalling pathways also contribute to tumorigenesis and cancer progression in a context-dependent manner. Aberrations in WNT signalling pathways and alterations in other oncogene and tumour suppressor pathways cooperate to drive cancer initiation and progression. Multiple strategies for...
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14. Mathur R, et al. Targeting Wnt pathway in mantle cell lymphoma-initiating cells.J Hematol Oncol. 2015 Jun 6;8:63.15. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling intissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.16. Huang SM, ...
10. Goldstein B, Takeshita H, Mizumoto K,Sawa H. Wnt signals can function as positional cues in establishing cellpolarity. Dev Cell. 2006 Mar;10(3):391-6. PubMed ID: 16516841 11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: ...
The cell-surface proteo- glycan Dally regulates Wingless signalling in Drosophila[J]. Nature, 1999, 400(6741):276-280. [91]Zhu F, Zhang X. The Wnt signaling pathway is involved in the regulation of phagocytosis of virus in Drosophila[J]. Entific Reports, 2013, 3 :2069. [92]Zhang S, ...
[Key words] Wnt signaling pathway;Apoptosis;Cancer therapy 各项研究充分表明,如果细胞凋亡发生失调,那么机体会出现多种疾病,当细胞凋亡不能正常进行时,会发生癌症;当细胞凋亡失调,特别是神经组织或肌肉组织发生病变时,会发生神经或肌肉细胞的功能丧失,导致功能性失常和障碍[1]。大量研究表明,Wnt信号通路在生物体的...