Wntpathwaygenes•Feedbackloop•MutantWntPathwayPhenotypes–WntRedundancy•WntandHumanDisease•SummaryIntroduction•Importantinmultipledevelopmentalevents–Mutated:leadstodisease•Canonicalpathway:–WntsignalingthroughFrizzledtoβ-catenin•Mainintracellularproteinsinvolved:–Dishevelled(Dsh)-Glycogensynthasekinase3...
Wnt signaling pathwaysSummary Current evidence suggests that in addition to the specific combination of Wnt ligands and receptors, endocytosis of the Wnt-receptor complex, binding of Wnt to heparan sulfate proteoglycans (HSPGs), and ubiquitination of Wnt receptors are involved in the regulation of ...
Wnt signalingis a conserved signaling pathway among species, controlling various biological processes ranging from development, homeostasis, healing, and regeneration (Komiya & Habas, 2008). Wnt signaling controls many cellular responses, e.g. cell proliferation, cell cycle progression, cell fate determin...
WNT inhibits glycogen synthase kinase 3β (GSK3β) leading to an increase of intracellular β-Catenin. The non-canonical WNT signalling can act as positive regulator of ERK1/2 pathway which ultimately impacts on
Considering that ICG001 could reduce TGF-β, TGF-β might be the mediator in the regulation of KLF5, immune activation, and the Wnt/β-catenin signaling pathway. The upregulation of TGF-β is persistent for at least 4–8 weeks when fibronectin and collagen are expressed in cardiac tissues45...
Summary The creation of a functional 3D bioprinted human heart remains challenging, largely due to the lack of some crucial cardiac cell types, including the atrioventricular canal (AVC) cardiomyocytes, which are essential to slow down the electrical impulse between the atrium and ventricle. By utili...
116, 117 In summary, Flamingo would seem to participate in the orienting of fly hair via a PCP pathway. In vertebrates, ear hair cells have microtubule cilia that extend from one particular side of each cell. All cilia point in the same direction. In mice, when putative mouse orthologs of...
stage of embryogenesis. Inhibition of Wnt signaling is beneficial for cardiac wound healing and functional recovery after injury. Understanding of the roles and mechanisms of Wnt signaling pathway in injured animal hearts will...
Summary Canonical Wnt signaling has been implicated in the regulation of hematopoiesis. By employing a Wnt-reporter mouse, we observed that Wnt signaling i... Tiago C.,Luis,and,... - 《Cell Stem Cell》 被引量: 322发表: 2011年 The canonical Wnt signaling pathway plays an important role in...
Summary The vertebrate body forms in an anterior-to-posterior progression, driven by a population of undifferentiated cells at the posterior-most end of the embryo. Recent studies have demonstrated that these undifferentiated cells are multipotent stem cells, suggesting that local signaling factors specif...