Wnt/β-catenin pathway mechanismsWnt/Wg signaling pathwaySummary In this chapter, the authors discuss the insights they have gained into the molecular regulation of the canonical Wnt signaling pathway from global RNAi screens. The main function of the canonical Wnt pathway is to regulate the ...
When Wnt signaling in preadipocytes is prevented by overexpression of axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro. In summary, Wnt signaling functions as an adipogenic switch....
Wntpathwaygenes •Feedbackloop •MutantWntPathway Phenotypes –WntRedundancy •WntandHumanDisease •Summary Introduction •Importantinmultipledevelopmentalevents –Mutated:leadstodisease •Canonicalpathway: –WntsignalingthroughFrizzledtoβ-catenin •Mainintracellularproteinsinvolved: –Dishevelled(Dsh)-...
Wnt-β catenin is an important signaling pathway in the genesis of fibrosis in many organ systems. Our goal was to examine the role of Wnt pathway in the external anal sphincter (EAS) injury-related fibrosis and muscle dysfunction. New Zealand White female rabbits were subjected to surgical EAS...
Wnt signaling triggered by chronic hyperglycemia is involved in the pathogenesis of diabetic osteoporosis. There are two main types of Wnt signaling pathways, the canonical Wnt signaling pathway (β-catenin-dependent) and the non-canonical Wnt signaling pathway (non-β-catenin-dependent), both of ...
In summary, activation of canonical Wnt-signaling pathway via Wnt3A and hCG from developing embryo with circulatory P4 may pre-dispose the Fallopian tubal environment more susceptible to the embryo attachment thus playing a vital role in the aetiology of TEP. Financial assistance given by RCG grant...
Further information on research design is available in theNature Research Reporting Summarylinked to this article. Results FMRP is upregulated in GSCs due to enhancedFMR1mRNA translation To address whether FMRP is involved in the biology of GBM, we investigated its expression in different GBM biopsies...
SummaryAdvances in multiple myeloma support the notion that the associated bone disease, characterized by increased osteoclastogenesis and suppressed osteo... Shmuel,Yaccoby - 《British Journal of Haematology》 被引量: 120发表: 2010年 Advances in the biology and treatment of myeloma bone disease. The...
Summary Dysregulation of Wnt signaling is closely associated with human liver tumorigenesis. However, liver cancer-specific Wnt transcriptional programs an... Jiayi Wang and Joo-Seop Park and Yingying Wei and Mihir Rajurkar and Jennifer L. Cotton and Qishi Fan and Brian C. Lewis and Hongkai Ji ...
Chemical genomics is a powerful method to complement more traditional genetic techniques (i.e. knockout mice, siRNA) for the dissection of complex signaling networks. Wnt signaling in mammals is a complex and crucial regulator of diverse functions. The Wnt-β-catenin pathway initiates a signaling ...