These results indicate that FRAT2, just like FRAT1, functions as a positive regulator of the WNT signaling pathway. Thus, up-regulation of FRAT2 in human cancer might be implicated in carcinogenesis through activation of the WNT signaling pathway....
In contrast, ventral injection of synthetic WNT2B2 mRNA induced axis duplication in 90% of embryos (complete axis duplication, 24%). These results strongly suggest that WNT2B2 up-regulation in some cases of gastric cancer might lead to carcinogenesis through activation of the β-catenin–TCF ...
Of the multiple Wnt signaling pathways, DKK1 inhibits the β-catenin-dependent pathway (β-catenin pathway) [1,2]. DKK1 induces depalmitoylation and internalization of low-density lipoprotein receptor-related protein 6 (LRP6), a Wnt co-receptor, through a clathrin-mediated route, resulting in rem...
Pdgfr Signaling Tyr-857 has therefore been assigned a role in positive regulation of kinase activity. Search Transcriptomic and chemical substance looks at to distinguish prospect family genes Posted onNovember 16, 2024 Reply A 72-year-old lady with averagely differentiated periampullary adenocarcinoma ...
Upregulation of miR-378a-5p in M14 melanoma cells reduced both mRNA (Supplementary Fig. 1a) and protein (Supplementary Fig. 1b) levels of STAMBP, SP1, KLF9, FUS-1, and SUFU when compared with control transfected cells, while miR-378a-5p inhibition led to an opposite effect, upregulating...
The Wnt/β-catenin pathway plays an essential role in pigmentation by regulating both melanocyte differentiation and melanogenesis through the action of MITF.4β-catenin is increased by the binding of Wnt proteins to their receptors, lead...
Mir-195-5p is critical in REGγ-mediated regulation of wnt/β-catenin pathway in renal cell carcinoma. Oncotarget. 2017;8(38):63986–4000. 67. Yen Y-T, Yang J-C, Chang J-B, Tsai S-C. Down-regulation of mir-194-5p for Predicting Metastasis in Breast Cancer cells. Int J Mol Sci...
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Down-regulation of miR-550a-3-5p correlated with HPV-positive OSCC metastasis A total of 70 clinical specimens of OSCC were detected for HPV status using PCR analysis of extracted DNA (Supplementary Fig. 1A). HPV was detected in 25/70 (35.7%) patient samples, with HPV16 ranking the most ...
Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signalling and considered both a cancer stem cell marker and intestinal stem cell marker. We found first some splice variants of LGR5 in human intestine and elucidated the functional feature of full-length LG...