The predicted amino acid sequence of this GSK-3β-interacting protein shows 94% identity with mouse Axin, which recently has been identified as a negative regulator of the Wnt signaling pathway; therefore, we termed this protein rAxin (rat Axin). rAxin interacted directly with, and was ...
kidney development WID, a novel negative regulator of the WNT signaling pathway, is important for kidney developmentWID, a novel negative regulator of the WNT signaling pathway, is important for kidney developmentPublication » WID, a novel negative regulator of the WNT signaling pathway, is ...
Because of the high structural homology between slimb and βTrCP, it is of particular interest to examine whether β-TrCP is involved in the regulation of the Wnt/β-catenin signaling pathway in vertebrates. In this study, we examined the role of β-TrCP in Xenopus early development, ...
The involvement of trimeric G protein signaling in the regulation of Wnt signaling was suggested by the finding that Frizzled interacts with the Gα subunit of trimeric G proteins in mammalian cells and that G protein signaling directly transduces Frizzled signaling inDrosophila(Katanaev et al., 200...
Significantly, Vldlr-/- mice showed impaired phosphorylation of downstream effectors of the wnt signaling pathway, GSK-3β and β-catenin, concomitant with increased levels of free GSK-3β and β-catenin, suggesting an increased activity of the wnt pathway. Down-regulation of VLDLR by siRNA ...
Research from JAMA Internal Medicine — A Negative Trial of Inpatient Geriatric Consultation — Lessons Learned and Recommendations for Future Research Winograd,Carol,H. - 《Archives of Internal Medicine》 被引量: 3095发表: 1993年 Axin, a negative regulator of the Wnt signaling pathway, forms a ...
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PCDH10 inhibits cell proliferation of multiple myeloma via the negative regulation of the Wnt/beta-catenin/BCL-9 signaling pathway Q and Chen J: PCDH10 inhibits cell proliferation of multiple myeloma via the negative regulation of the Wnt/β‑catenin/BCL‑9 signaling pathway. ... Liu,Qiong,...
1 However, breast cancer is a complex, heterogeneous disease characterized by a great multitude of aberrations at the genomic and molecular level, which can manifest in dysregulated signaling pathways. A hallmark of many cancers is aberrant regulation of the Wnt signaling pathway, and breast cancer ...
Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review...