10. Goldstein B, Takeshita H, Mizumoto K,Sawa H. Wnt signals can function as positional cues in establishing cellpolarity. Dev Cell. 2006 Mar;10(3):391-6. PubMed ID: 16516841 11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 1...
Wnt signals can function as positional cues in establishing cellpolarity. Dev Cell. 2006 Mar;10(3):391-6. PubMed ID: 1651684111. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 1627326012. Tim...
10. Goldstein B, Takeshita H, Mizumoto K,Sawa H. Wnt signals can function as positional cues in establishing cellpolarity. Dev Cell. 2006 Mar;10(3):391-6. PubMed ID: 16516841 11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 1...
10. Goldstein B, Takeshita H, Mizumoto K,Sawa H. Wnt signals can function as positional cues in establishing cellpolarity. Dev Cell. 2006 Mar;10(3):391-6. PubMed ID: 16516841 11. Katoh M. WNT/PCP signaling pathway andhuman cancer. Oncol Rep. 2005 Dec;14(6):1583-8. PubMed ID: 1...
关键词:Wnt 信号通路;线粒体;代谢紊乱;神经退行性疾病;肿瘤WntSignalingPathwayinMitochondrial FunctionRegulationandRelatedDiseases QIAO Xue 1,2a ,ZHU Li 1 ,GUO Yan 1,2a ,SONG Rongbo 1 ,ZHONG Ming 1,2b . (1. Department of Central Laboratory,School of Stomatology,China Medi-cal University/ Key ...
In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2 (Rocheleau 1997). In addition to porcupine, several other proteins, including the transmembrane Wls/Evi are specifically involved in Wnt secretion (Banziger, 2006;Bartscherer, 2006...
[2] Liu J, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022 Jan 3;7(1):3. [3] Chang L, et al. Systematic profiling of conditional pathway activation...
发表在 Nat Genet 上的文章“Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities ”指出:过度激活 Wnt/β-catenin 信号通路,非但没有促进癌症的发展,反而显示出抗癌活性(肿瘤细胞可能无法容忍已经激活的 Wnt/β-catenin 通路再进一步激活,从而导致其生存受影响)。
[2] Liu J, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022 Jan 3;7(1):3. [3] Chang L, et al. Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities. Nat Genet...
Four mechanisms are known to be involved in the activation of the Wnt signaling in tumor cells. These include the loss-of-function mutation of the gene APC, gain-of-function mutation of β-catenin, overexpression of the Wnt ligands or Wnt receptor, and the reduced expression of the Wnt nega...