[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epit...
The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets. Pharm. Ther. 138, 66-83.Baarsma, H. A., Ko¨nigshoff, M., and Gosens, R. (2013) The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms...
[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epit...
The Wnt gene is synonymous with the Drosophila segment polarity gene Wingless and the murine proto-oncogene integration 1, which was molecularly characterized from mouse tumor cells in 1982 [14]. This signaling pathway is a family consisting of two distinct pathways: the noncanonical and canonical p...
摘要: This study was designed to investigate whether genetic polymorphisms of the Wnt/β-catenin signaling pathway and its interactions are involved in the development of knee osteoarthritis (KOA). Patients...关键词: Gene–gene interactions Wnt/β-catenin signaling pathway Osteoarthritis SNPs ...
in cBioPortal/GBM or in both of the CLIP studies. The overlap (73 genes) of the genes frequently mutated in GBM (see above) and the list of genes associated with autism (1023 genes, Simons Foundation Autism Research Initiative, SFARI,https://gene.sfari.org) was analyzed in the same way...
[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epit...
Using a support vector machine classifier method, 16 genes out of the 64 were identified as a gene expression signature for the Wnt/β-catenin signaling pathway. The sensitivity of identified gene expression signature was assessed using LNCaP and SW480 cells treated with pyrvinium, a Wnt/β-...
Wnt activity reduction was not associated with altered pluripotency gene expression, but it was translated into impaired differentiation potential, faster cell cycle progression and genomic instability, thus loss of mESC homeostasis. The factors causing Wnt/β-catenin pathway downregulation in prolonged ...
Wnt proteins can transduce their signaling through distinct intracellular routes which can be divided into two pathways as either 'canonical or 'non-canonical" Wnt pathways. The best understood canonical pathway utilizes nuclear β-catenin as an ultimate effector, leading to changes in gene expression...